Ajaikumar B Kunnumakkara
Overview
Explore the profile of Ajaikumar B Kunnumakkara including associated specialties, affiliations and a list of published articles.
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Articles
187
Citations
11664
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Recent Articles
1.
Aswani B, Sajeev A, Hegde M, Mishra A, Abbas M, Vayalpurayil T, et al.
Mech Ageing Dev
. 2025 Mar;
:112045.
PMID: 40074065
Cancer remains one of the most devastating diseases, severely affecting public health and contributing to economic instability. Researchers worldwide are dedicated to developing effective therapeutics to target cancer cells. One...
2.
Sailo B, Garhwal A, Mishra A, Hegde M, Vishwa R, Girisa S, et al.
Biochem Pharmacol
. 2025 Mar;
:116828.
PMID: 40023449
Capsaicin (CAPS), a bioactive alkaloid derived from chili peppers, has garnered significant interest for its potential role as a combinatorial and chemosensitizing agent in cancer therapy. Numerous preclinical studies have...
3.
Sailo B, Vishwa R, Girisa S, Aswani B, Abbas M, AlQahtani M, et al.
Curr Top Med Chem
. 2025 Feb;
PMID: 40017244
Genistein (GEN), a phytoestrogen primarily sourced from soy plants, is recognized for its anticancer properties attributed to its roles as a tyrosine kinase inhibitor, an estrogen receptor agonist, and its...
4.
Kumar A, Yap K, BharathwajChetty B, Lyu J, Hegde M, Abbas M, et al.
J Biomed Sci
. 2024 Dec;
31(1):105.
PMID: 39716252
The increasing prevalence of chronic diseases and their associated morbidities demands a deeper understanding of underlying mechanism and causative factors, with the hope of developing novel therapeutic strategies. Autophagy, a...
5.
Mehta K, Hegde M, Girisa S, Vishwa R, AlQahtani M, Abbas M, et al.
Mil Med Res
. 2024 Dec;
11(1):76.
PMID: 39668367
The extensive heterogeneity and the limited availability of effective targeted therapies contribute to the challenging prognosis and restricted survival observed in triple-negative breast cancer (TNBC). Recent research indicates the aberrant...
6.
Bintee B, Banerjee R, Hegde M, Vishwa R, AlQahtani M, Abbas M, et al.
Cancer Lett
. 2024 Nov;
609:217324.
PMID: 39571783
Bile acid transporters (BATs) are integral membrane proteins belonging to various families, such as solute carriers, organic anion transporters, and ATP-binding cassette families. These transporters play a crucial role in...
7.
Aswani B, Hegde M, Vishwa R, AlQahtani M, Abbas M, Almubarak H, et al.
Mil Med Res
. 2024 Sep;
11(1):67.
PMID: 39327610
Nuclear receptors (NRs) function as crucial transcription factors in orchestrating essential functions within the realms of development, host defense, and homeostasis of body. NRs have garnered increased attention due to...
8.
Manickasamy M, Kumar A, BharathwajChetty B, AlQahtani M, Abbas M, Alqahtani A, et al.
Life Sci
. 2024 Aug;
354:122943.
PMID: 39117139
Despite significant advancements in chemotherapy, effective treatments for advanced cancer stages remain largely elusive due to chemoresistance. Resistance to anticancer agents in cancer cells can arise through various mechanisms, including...
9.
Sajeev A, BharathwajChetty B, Manickasamy M, AlQahtani M, Abbas M, Shakibaei M, et al.
Front Oncol
. 2024 Jul;
14:1383939.
PMID: 39077471
Ovarian cancer (OVC) is one of the most common causes of cancer-related deaths in women worldwide. Despite advancements in detection and therapy, the prognosis of OVC remains poor due to...
10.
Wadhwa R, Hegde M, Zhang H, Kaul A, Wang J, Ishida Y, et al.
Appl Biochem Biotechnol
. 2024 Jun;
196(12):8791-8808.
PMID: 38941028
Chronic stress has been linked to a large number of pathologies, including cancer, premature aging, and neurodegenerative diseases. The accumulation of molecular waste resulting from oxidative and heavy metal-induced stress...