Kuzhuvelil B Harikumar
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Explore the profile of Kuzhuvelil B Harikumar including associated specialties, affiliations and a list of published articles.
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53
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5216
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Recent Articles
1.
Keerthana C, Aiswarya S, Rayginia T, Vijayan Y, James S, Shifana S, et al.
Anticancer Agents Med Chem
. 2024 Aug;
24(19):1431-1441.
PMID: 39129290
Introduction: Sorafenib (Sor) is the first-line treatment option in clinics for treating advanced unresectable hepatocellular carcinoma (HCC). However, acquired chemoresistance and adverse side effects associated with Sor monotherapy limit its...
2.
Vijayan Y, Sandhu J, Harikumar K
Curr Med Chem
. 2024 Mar;
31(32):5165-5177.
PMID: 38549529
Immunotherapy is a newly emerging and effective approach to treating cancer. However, there are many challenges associated with using checkpoint inhibitors in this treatment strategy. The component of the tumor...
3.
Baby B, Kulkarni A, Gayam P, Harikumar K, Aranjani J
Arch Biochem Biophys
. 2024 Mar;
754:109952.
PMID: 38432565
Hedgehog (Hh) signaling plays a significant role in embryogenesis and several physiological processes, such as wound healing and organ homeostasis. In a pathological setting, it is associated with oncogenesis and...
4.
Vijayan Y, James S, Viswanathan A, Aparna J, Bindu A, Namitha N, et al.
J Adv Res
. 2023 Dec;
65:73-87.
PMID: 38142035
Introduction: Acid ceramidase (hereafter referred as ASAH1) is an enzyme in sphingolipid metabolism that converts pro-survival ceramide into sphingosine. ASAH1 has been shown to be overexpressed in certain cancers. However,...
5.
Mohammed S, Bindu A, Viswanathan A, Harikumar K
Prog Lipid Res
. 2023 Aug;
92:101251.
PMID: 37633365
Sphingolipids are essential components of all eukaryotic membranes. The bioactive sphingolipid molecule, Sphingosine 1-Phosphate (S1P), regulates various important biological functions. This review aims to provide a comprehensive overview of the...
6.
Baby K, Maity S, Mehta C, Nayak U, Shenoy G, Pai K, et al.
Sci Rep
. 2023 May;
13(1):7947.
PMID: 37193898
Non-small cell lung carcinomas (NSCLC) are the predominant form of lung malignancy and the reason for the highest number of cancer-related deaths. Widespread deregulation of Akt, a serine/threonine kinase, has...
7.
Suresh D, Srinivas A, Prashant A, Harikumar K, Kumar D
Clin Exp Med
. 2023 Feb;
23(6):1901-1916.
PMID: 36780119
Hepatocellular carcinoma (HCC) is a chronic liver disease that is highly fatal if not detected and treated early. The incidence and death rate of HCC have been increasing in recent...
8.
Augmented Efficacy of Uttroside B over Sorafenib in a Murine Model of Human Hepatocellular Carcinoma
Swetha M, Keerthana C, Rayginia T, Nath L, Haritha N, Shabna A, et al.
Pharmaceuticals (Basel)
. 2022 May;
15(5).
PMID: 35631464
We previously reported the remarkable potency of uttroside B (Utt-B), saponin-isolated and characterized in our lab from Linn, against HCC. Recently, the U.S. FDA approved Utt-B as an 'orphan drug'...
9.
Arndt C, Bergmann R, Striese F, Merkel K, Mathe D, Loureiro L, et al.
Cancers (Basel)
. 2022 Apr;
14(8).
PMID: 35454902
Due to its overexpression on the surface of prostate cancer (PCa) cells, the prostate stem cell antigen (PSCA) is a potential target for PCa diagnosis and therapy. Here we describe...
10.
Manu K, Harikumar K, Ishimoto T
Front Oncol
. 2022 Apr;
12:873682.
PMID: 35433449
No abstract available.