Kotaro Nakanishi
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Explore the profile of Kotaro Nakanishi including associated specialties, affiliations and a list of published articles.
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36
Citations
1314
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Recent Articles
11.
Nakanishi K
Nucleic Acids Res
. 2022 Jun;
50(12):6618-6638.
PMID: 35736234
MicroRNAs (miRNAs) bind to complementary target RNAs and regulate their gene expression post-transcriptionally. These non-coding regulatory RNAs become functional after loading into Argonaute (AGO) proteins to form the effector complexes....
12.
Nakanishi K
Front Mol Biosci
. 2021 Dec;
8:795356.
PMID: 34926585
The biosynthesis pathways of microRNAs (miRNAs) have been well characterized with the identification of the required components. miRNAs are synthesized from the transcripts of miRNA genes and other RNAs, such...
13.
Dayeh D, Cantara W, Kitzrow J, Musier-Forsyth K, Nakanishi K
Nucleic Acids Res
. 2021 Aug;
49(16):9606.
PMID: 34403465
No abstract available.
14.
Li Y, Chao T, Kim H, Cholko T, Chen S, Li G, et al.
Sci Adv
. 2021 Feb;
7(3).
PMID: 33523904
The Cdk8 kinase module (CKM) in Mediator, comprising Med13, Med12, CycC, and Cdk8, regulates RNA polymerase II transcription through kinase-dependent and -independent functions. Numerous pathogenic mutations causative for neurodevelopmental disorders...
15.
Park M, Sim G, Kehling A, Nakanishi K
Proc Natl Acad Sci U S A
. 2020 Oct;
117(46):28576-28578.
PMID: 33122430
RNA interfering is a eukaryote-specific gene silencing by 20∼23-nucleotide (nt) microRNAs and small interfering RNAs that recruit Argonaute proteins to complementary RNAs for degradation. In humans, Argonaute2 (AGO2) has been...
16.
Park M, Araya-Secchi R, Brackbill J, Phan H, Kehling A, Abd El-Wahab E, et al.
Mol Cell
. 2019 Jul;
75(4):725-740.e6.
PMID: 31324450
Despite the relevance of Argonaute proteins in RNA silencing, little is known about the structural steps of small RNA loading to form RNA-induced silencing complexes (RISCs). We report the 1.9 ...
17.
Dayeh D, Cantara W, Kitzrow J, Musier-Forsyth K, Nakanishi K
Nucleic Acids Res
. 2018 Jun;
46(16):e98.
PMID: 29897478
The recent identification and development of RNA-guided enzymes for programmable cleavage of target nucleic acids offers exciting possibilities for both therapeutic and biotechnological applications. However, critical challenges such as expensive...
18.
Dayeh D, Kruithoff B, Nakanishi K
J Biol Chem
. 2018 Mar;
293(17):6308-6325.
PMID: 29519815
Some gene transcripts have cellular functions as regulatory noncoding RNAs. For example, ∼23-nucleotide (nt)-long siRNAs are loaded into Argonaute proteins. The resultant ribonucleoprotein assembly, the RNA-induced silencing complex (RISC), cleaves...
19.
Park M, Phan H, Busch F, Hinckley S, Brackbill J, Wysocki V, et al.
Nucleic Acids Res
. 2017 Oct;
45(20):11867-11877.
PMID: 29040713
Of the four human Argonaute (AGO) paralogs, only AGO2 has been shown to have slicer activity. The others (AGO1, AGO3 and AGO4) have been thought to assemble with microRNAs to...
20.
Phan H, Li J, Poi M, Nakanishi K
Methods Mol Biol
. 2017 Oct;
1680:29-40.
PMID: 29030839
MicroRNAs (miRNAs) are small non-coding RNAs that trigger post-transcriptional gene silencing. These RNAs need to be associated with the Argonaute proteins to be functional. This assembly begins with loading of...