GeunYoung Sim
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Explore the profile of GeunYoung Sim including associated specialties, affiliations and a list of published articles.
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6
Citations
33
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Recent Articles
1.
Voss D, Kral A, Sim G, Utama R, Lin K, Cizmeciyan C, et al.
J Biol Chem
. 2025 Feb;
:108345.
PMID: 39993527
Pyruvate kinase M isoform 2 (PKM2) is preferentially expressed in nearly all cancers. It primarily functions as the last enzyme in glycolysis, but has other reported non-canonical functions, including recruiting...
2.
Zhang H, Sim G, Kehling A, Adhav V, Savidge A, Pastore B, et al.
Cell Rep
. 2024 Oct;
43(10):114806.
PMID: 39368090
TinyRNAs (tyRNAs) are ≤17-nt guide RNAs associated with Argonaute proteins (AGOs), and certain 14-nt cleavage-inducing tyRNAs (cityRNAs) catalytically activate human Argonaute3 (AGO3). We present the crystal structure of AGO3 in...
3.
Sim G, Kehling A, Park M, Divoky C, Zhang H, Malhotra N, et al.
bioRxiv
. 2023 Nov;
PMID: 37961191
MicroRNAs (miRNAs) and small interfering RNAs (siRNAs) are loaded into Argonaute (AGO) proteins, forming RNA-induced silencing complexes (RISCs). The assembly process establishes the seed, central, 3' supplementary, and tail regions...
4.
Sim G, Kehling A, Park M, Divoky C, Zhang H, Malhotra N, et al.
Sci Rep
. 2023 Nov;
13(1):19761.
PMID: 37957252
MicroRNAs (miRNAs) and small interfering RNAs (siRNAs) are loaded into Argonaute (AGO) proteins, forming RNA-induced silencing complexes (RISCs). The assembly process establishes the seed, central, 3' supplementary, and tail regions...
5.
Sim G, Kehling A, Park M, Secor J, Divoky C, Zhang H, et al.
Proc Natl Acad Sci U S A
. 2022 Dec;
119(51):e2214335119.
PMID: 36508664
MicroRNAs (miRNAs) are about 22-nucleotide (nt) noncoding RNAs forming the effector complexes with Argonaute (AGO) proteins to repress gene expression. Although tiny RNAs (tyRNAs) shorter than 19 nt have been...
6.
Park M, Sim G, Kehling A, Nakanishi K
Proc Natl Acad Sci U S A
. 2020 Oct;
117(46):28576-28578.
PMID: 33122430
RNA interfering is a eukaryote-specific gene silencing by 20∼23-nucleotide (nt) microRNAs and small interfering RNAs that recruit Argonaute proteins to complementary RNAs for degradation. In humans, Argonaute2 (AGO2) has been...
7.
Song M, Cho A, Sim G, Ahn J
J Agric Food Chem
. 2019 Jan;
67(7):2028-2035.
PMID: 30698011
Caffeic acid phenethyl ester (CAPE) is an ester of a hydroxycinnamic acid (phenylpropanoid) and a phenylethanoid (2-phenylethanol; 2-PE), which has long been used in traditional medicine. Here, we synthesized 54...