Audrey C Kehling
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Explore the profile of Audrey C Kehling including associated specialties, affiliations and a list of published articles.
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6
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52
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Recent Articles
1.
Zhang H, Sim G, Kehling A, Adhav V, Savidge A, Pastore B, et al.
Cell Rep
. 2024 Oct;
43(10):114806.
PMID: 39368090
TinyRNAs (tyRNAs) are ≤17-nt guide RNAs associated with Argonaute proteins (AGOs), and certain 14-nt cleavage-inducing tyRNAs (cityRNAs) catalytically activate human Argonaute3 (AGO3). We present the crystal structure of AGO3 in...
2.
Sim G, Kehling A, Park M, Divoky C, Zhang H, Malhotra N, et al.
bioRxiv
. 2023 Nov;
PMID: 37961191
MicroRNAs (miRNAs) and small interfering RNAs (siRNAs) are loaded into Argonaute (AGO) proteins, forming RNA-induced silencing complexes (RISCs). The assembly process establishes the seed, central, 3' supplementary, and tail regions...
3.
Sim G, Kehling A, Park M, Divoky C, Zhang H, Malhotra N, et al.
Sci Rep
. 2023 Nov;
13(1):19761.
PMID: 37957252
MicroRNAs (miRNAs) and small interfering RNAs (siRNAs) are loaded into Argonaute (AGO) proteins, forming RNA-induced silencing complexes (RISCs). The assembly process establishes the seed, central, 3' supplementary, and tail regions...
4.
Sim G, Kehling A, Park M, Secor J, Divoky C, Zhang H, et al.
Proc Natl Acad Sci U S A
. 2022 Dec;
119(51):e2214335119.
PMID: 36508664
MicroRNAs (miRNAs) are about 22-nucleotide (nt) noncoding RNAs forming the effector complexes with Argonaute (AGO) proteins to repress gene expression. Although tiny RNAs (tyRNAs) shorter than 19 nt have been...
5.
Park M, Sim G, Kehling A, Nakanishi K
Proc Natl Acad Sci U S A
. 2020 Oct;
117(46):28576-28578.
PMID: 33122430
RNA interfering is a eukaryote-specific gene silencing by 20∼23-nucleotide (nt) microRNAs and small interfering RNAs that recruit Argonaute proteins to complementary RNAs for degradation. In humans, Argonaute2 (AGO2) has been...
6.
Park M, Araya-Secchi R, Brackbill J, Phan H, Kehling A, Abd El-Wahab E, et al.
Mol Cell
. 2019 Jul;
75(4):725-740.e6.
PMID: 31324450
Despite the relevance of Argonaute proteins in RNA silencing, little is known about the structural steps of small RNA loading to form RNA-induced silencing complexes (RISCs). We report the 1.9 ...