Koen W R van Cleef
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Explore the profile of Koen W R van Cleef including associated specialties, affiliations and a list of published articles.
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20
Citations
578
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Recent Articles
1.
Damen M, Izidoro M, Okamoto D, Oliveira L, Amatdjais-Groenen H, van Dongen S, et al.
Molecules
. 2022 May;
27(10).
PMID: 35630694
Dengue is an important arboviral infectious disease for which there is currently no specific cure. We report gemini-like (geminoid) alkylated amphiphilic peptides containing lysines in combination with glycines or alanines...
2.
Bezemer B, van Cleef K, Overheul G, Miesen P, van Rij R
Antiviral Res
. 2022 Apr;
202:105313.
PMID: 35367280
After decades of being considered non-pathogenic, Zika virus (ZIKV) emerged as an important threat to human health during the epidemic of 2015-2016. ZIKV infections are usually asymptomatic, but can cause...
3.
Meutiawati F, Bezemer B, Strating J, Overheul G, Zusinaite E, van Kuppeveld F, et al.
Antiviral Res
. 2018 Jul;
157:68-79.
PMID: 29981375
Dengue virus (DENV) is associated with an estimated 390 million infections per year, occurring across approximately 100 countries in tropical and sub-tropical regions. To date, there are no antiviral drugs...
4.
van Cleef K, Overheul G, Thomassen M, Marjakangas J, van Rij R
Antimicrob Agents Chemother
. 2016 Feb;
60(4):2554-7.
PMID: 26856827
Despite the enormous disease burden associated with dengue virus infections, a licensed antiviral drug is lacking. Here, we show that the paracetamol (acetaminophen) metabolite AM404 inhibits dengue virus replication. Moreover,...
5.
Bronkhorst A, van Cleef K, Venselaar H, van Rij R
Nucleic Acids Res
. 2014 Oct;
42(19):12237-48.
PMID: 25274730
Invertebrate RNA viruses are targets of the host RNA interference (RNAi) pathway, which limits virus infection by degrading viral RNA substrates. Several insect RNA viruses encode suppressor proteins to counteract...
6.
Schuster S, Zirkel F, Kurth A, van Cleef K, Drosten C, van Rij R, et al.
J Virol
. 2014 Sep;
88(22):13447-59.
PMID: 25210176
Unlabelled: Insects are a reservoir for many known and novel viruses. We discovered an unknown virus, tentatively named mosinovirus (MoNV), in mosquitoes from a tropical rainforest region in Côte d'Ivoire....
7.
van Mierlo J, Overheul G, Obadia B, van Cleef K, Webster C, Saleh M, et al.
PLoS Pathog
. 2014 Jul;
10(7):e1004256.
PMID: 25032815
The ongoing conflict between viruses and their hosts can drive the co-evolution between host immune genes and viral suppressors of immunity. It has been suggested that an evolutionary 'arms race'...
8.
van Cleef K, van Mierlo J, Miesen P, Overheul G, Fros J, Schuster S, et al.
Nucleic Acids Res
. 2014 Jun;
42(13):8732-44.
PMID: 24939903
RNA interference (RNAi) is a crucial antiviral defense mechanism in insects, including the major mosquito species that transmit important human viruses. To counteract the potent antiviral RNAi pathway, insect viruses...
9.
van Cleef K, Overheul G, Thomassen M, Kaptein S, Davidson A, Jacobs M, et al.
Antiviral Res
. 2013 Jun;
99(2):165-71.
PMID: 23735301
Dengue virus (DENV) is an important human arthropod-borne virus with a major impact on public health. Nevertheless, a licensed vaccine or specific treatment is still lacking. We therefore screened the...
10.
Bronkhorst A, van Cleef K, Vodovar N, Ince I, Blanc H, Vlak J, et al.
Proc Natl Acad Sci U S A
. 2012 Nov;
109(51):E3604-13.
PMID: 23151511
RNA viruses in insects are targets of an RNA interference (RNAi)-based antiviral immune response, in which viral replication intermediates or viral dsRNA genomes are processed by Dicer-2 (Dcr-2) into viral...