Joel T van Mierlo
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Explore the profile of Joel T van Mierlo including associated specialties, affiliations and a list of published articles.
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10
Citations
319
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Recent Articles
1.
Witte S, Huijboom L, Klamert S, van de Straat L, Hagens S, Fieseler L, et al.
Food Microbiol
. 2022 Mar;
104:103978.
PMID: 35287807
Shiga toxin producing Escherichia coli (STEC) are common etiological agents of food borne illnesses and outbreaks, most often caused by consuming contaminated beef products, followed by raw vegetables and dairy...
2.
Witte S, Zinsli L, Gonzalez-Serrano R, Matter C, Loessner M, van Mierlo J, et al.
Comput Struct Biotechnol J
. 2021 Jul;
19:3416-3426.
PMID: 34194667
Bacteriophages (phages) are widely used as biocontrol agents in food and as antibacterial agents for treatment of food production plant surfaces. An important feature of such phages is broad infectivity...
3.
Merkling S, Overheul G, van Mierlo J, Arends D, Gilissen C, van Rij R
Sci Rep
. 2015 Aug;
5:12758.
PMID: 26234525
Innate immunity is the first line of defence against pathogens and is essential for survival of the infected host. The fruit fly Drosophila melanogaster is an emerging model to study...
4.
van Mierlo J, Overheul G, Obadia B, van Cleef K, Webster C, Saleh M, et al.
PLoS Pathog
. 2014 Jul;
10(7):e1004256.
PMID: 25032815
The ongoing conflict between viruses and their hosts can drive the co-evolution between host immune genes and viral suppressors of immunity. It has been suggested that an evolutionary 'arms race'...
5.
van Cleef K, van Mierlo J, Miesen P, Overheul G, Fros J, Schuster S, et al.
Nucleic Acids Res
. 2014 Jun;
42(13):8732-44.
PMID: 24939903
RNA interference (RNAi) is a crucial antiviral defense mechanism in insects, including the major mosquito species that transmit important human viruses. To counteract the potent antiviral RNAi pathway, insect viruses...
6.
van Mierlo J, Bronkhorst A, Overheul G, Sadanandan S, Ekstrom J, Heestermans M, et al.
PLoS Pathog
. 2012 Aug;
8(8):e1002872.
PMID: 22916019
RNA interference (RNAi) is a major antiviral pathway that shapes evolution of RNA viruses. We show here that Nora virus, a natural Drosophila pathogen, is both a target and suppressor...
7.
van Cleef K, van Mierlo J, van den Beek M, van Rij R
Methods Mol Biol
. 2011 Mar;
721:201-13.
PMID: 21431687
The RNA interference (RNAi) pathway plays an important role in antiviral immunity in insects. To -counteract the RNAi-mediated immune response of their hosts, several insect viruses, such as Flock house...
8.
van Mierlo J, van Cleef K, van Rij R
Methods Mol Biol
. 2011 Mar;
721:3-22.
PMID: 21431676
RNA interference (RNAi) is an important pathway to combat virus infections in insects and plants. Hallmarks of antiviral RNAi in these organisms are: (1) an increase in virus replication after...
9.
Shi X, van Mierlo J, French A, Elliott R
J Virol
. 2010 Jun;
84(17):8460-9.
PMID: 20573824
The virion glycoproteins Gn and Gc of Bunyamwera virus (BUNV), the prototype of the Bunyaviridae family and also of the Orthobunyavirus genus, are encoded by the medium (M) RNA genome...
10.
van Mierlo J, van Cleef K, van Rij R
Cell Host Microbe
. 2010 Feb;
7(2):87-9.
PMID: 20159613
Virus-derived small interfering RNAs (siRNAs) are the hallmark of RNAi-based antiviral immunity. Wu and colleagues demonstrate how viral genomes can be assembled from these small RNA sequences. Their results provide...