Koen W R van Cleef
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Explore the profile of Koen W R van Cleef including associated specialties, affiliations and a list of published articles.
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20
Citations
578
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Recent Articles
11.
Vodovar N, Bronkhorst A, van Cleef K, Miesen P, Blanc H, van Rij R, et al.
PLoS One
. 2012 Feb;
7(1):e30861.
PMID: 22292064
The siRNA pathway is an essential antiviral mechanism in insects. Whether other RNA interference pathways are involved in antiviral defense remains unclear. Here, we report in cells derived from the...
12.
van Cleef K, van Mierlo J, van den Beek M, van Rij R
Methods Mol Biol
. 2011 Mar;
721:201-13.
PMID: 21431687
The RNA interference (RNAi) pathway plays an important role in antiviral immunity in insects. To -counteract the RNAi-mediated immune response of their hosts, several insect viruses, such as Flock house...
13.
van Mierlo J, van Cleef K, van Rij R
Methods Mol Biol
. 2011 Mar;
721:3-22.
PMID: 21431676
RNA interference (RNAi) is an important pathway to combat virus infections in insects and plants. Hallmarks of antiviral RNAi in these organisms are: (1) an increase in virus replication after...
14.
Aartsen W, van Cleef K, Pellissier L, Hoek R, Vos R, Blits B, et al.
PLoS One
. 2010 Sep;
5(8):e12387.
PMID: 20808778
Background: Müller cell gliosis occurs in various retinal pathologies regardless of the underlying cellular defect. Because activated Müller glial cells span the entire retina and align areas of injury, they...
15.
van Mierlo J, van Cleef K, van Rij R
Cell Host Microbe
. 2010 Feb;
7(2):87-9.
PMID: 20159613
Virus-derived small interfering RNAs (siRNAs) are the hallmark of RNAi-based antiviral immunity. Wu and colleagues demonstrate how viral genomes can be assembled from these small RNA sequences. Their results provide...
16.
Streblow D, van Cleef K, Kreklywich C, Meyer C, Smith P, DeFilippis V, et al.
J Virol
. 2007 Jan;
81(8):3816-26.
PMID: 17251289
Rat cytomegalovirus (RCMV) is a beta-herpesvirus with a 230-kbp genome containing over 167 open reading frames (ORFs). RCMV gene expression is tightly regulated in cultured cells, occurring in three distinct...
17.
van Cleef K, Smit M, Bruggeman C, Vink C
J Clin Virol
. 2006 Jan;
35(3):343-8.
PMID: 16406796
Background: Cytomegaloviruses (CMVs) have developed various sophisticated strategies to manipulate and evade the defense mechanisms of their hosts. Among the CMV genes that are predicted to be involved in these...
18.
van Cleef K, Scaf W, Maes K, Kaptein S, Beuken E, Beisser P, et al.
J Gen Virol
. 2004 Jun;
85(Pt 7):2001-2013.
PMID: 15218186
An intriguing feature of the rat cytomegalovirus (RCMV) genome is open reading frame (ORF) r127, which shows similarity to the rep genes of parvoviruses as well as the U94 genes...
19.
Kaptein S, van Cleef K, Gruijthuijsen Y, Beuken E, van Buggenhout L, Beisser P, et al.
Virus Genes
. 2004 Jun;
29(1):43-61.
PMID: 15215683
Rat cytomegalovirus (RCMV) possesses two adjacent genes, r131 and r129, which have the potential to encode CC chemokine homologs. Interestingly, the amino acid sequences encoded by both genes show similarity...
20.
Kaptein S, Beisser P, Gruijthuijsen Y, Savelkouls K, van Cleef K, Beuken E, et al.
J Gen Virol
. 2003 Aug;
84(Pt 9):2517-2530.
PMID: 12917474
The rat cytomegalovirus (RCMV) R33 and R78 genes are conserved within members of the subfamily Betaherpesvirinae and encode proteins (pR33 and pR78, respectively) that show sequence similarity with G protein-coupled...