Imre Schlemminger
Overview
Explore the profile of Imre Schlemminger including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
258
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Recent Articles
1.
Mole D, Schlemminger I, McNeill L, Hewitson K, Pugh C, Ratcliffe P, et al.
Bioorg Med Chem Lett
. 2003 Jul;
13(16):2677-80.
PMID: 12873492
Hydroxylation of hypoxia-inducible factor, a nuclear transcription factor, is catalysed by iron and 2-oxoglutarate dependent hydroxylases. Various analogues of the 2-oxoglutarate cosubstrate were synthesised and shown to inhibit the activity...
2.
Schlemminger I, Mole D, McNeill L, Dhanda A, Hewitson K, Tian Y, et al.
Bioorg Med Chem Lett
. 2003 Apr;
13(8):1451-4.
PMID: 12668010
Analogues of the naturally occurring cyclic hydroxamate dealanylalahopcin, which is an inhibitor of procollagen prolyl-4-hydroxylase, were synthesised and shown to be inhibitors of the human hypoxia-inducible factor prolyl hydroxylases.
3.
Welford R, Schlemminger I, McNeill L, Hewitson K, Schofield C
J Biol Chem
. 2003 Jan;
278(12):10157-61.
PMID: 12517755
AlkB is one of four proteins involved in the adaptive response to DNA alkylation damage in Escherichia coli and is highly conserved from bacteria to humans. Recent analyses have verified...
4.
Elkins J, Hewitson K, McNeill L, Seibel J, Schlemminger I, Pugh C, et al.
J Biol Chem
. 2002 Nov;
278(3):1802-6.
PMID: 12446723
The activity of the transcription factor hypoxia-inducible factor (HIF) is regulated by oxygen-dependent hydroxylation. Under normoxic conditions, hydroxylation of proline residues triggers destruction of its alpha-subunit while hydroxylation of Asn(803)...