Kirsty S Hewitson
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Explore the profile of Kirsty S Hewitson including associated specialties, affiliations and a list of published articles.
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38
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2554
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Recent Articles
11.
Coleman M, McDonough M, Hewitson K, Coles C, Mecinovic J, Edelmann M, et al.
J Biol Chem
. 2007 Jun;
282(33):24027-38.
PMID: 17573339
The stability and activity of hypoxia-inducible factor (HIF) are regulated by the post-translational hydroxylation of specific prolyl and asparaginyl residues. We show that the HIF asparaginyl hydroxylase, factor inhibiting HIF...
12.
Hewitson K, Lienard B, McDonough M, Clifton I, Butler D, Soares A, et al.
J Biol Chem
. 2006 Dec;
282(5):3293-301.
PMID: 17135241
In humans both the levels and activity of the alpha-subunit of the hypoxia-inducible transcription factor (HIF-alpha) are regulated by its post-translation hydroxylation as catalyzed by iron- and 2-oxoglutarate (2OG)-dependent prolyl...
13.
Cockman M, Lancaster D, Stolze I, Hewitson K, McDonough M, Coleman M, et al.
Proc Natl Acad Sci U S A
. 2006 Sep;
103(40):14767-72.
PMID: 17003112
Studies on hypoxia-sensitive pathways have revealed a series of Fe(II)-dependent dioxygenases that regulate hypoxia-inducible factor (HIF) by prolyl and asparaginyl hydroxylation. The recognition of these unprecedented signaling processes has led...
14.
Ehrismann D, Flashman E, Genn D, Mathioudakis N, Hewitson K, Ratcliffe P, et al.
Biochem J
. 2006 Sep;
401(1):227-34.
PMID: 16952279
The activity and levels of the metazoan HIF (hypoxia-inducible factor) are regulated by its hydroxylation, catalysed by 2OG (2-oxoglutarate)- and Fe(II)-dependent dioxygenases. An oxygen consumption assay was developed and used...
15.
McNeill L, Flashman E, Buck M, Hewitson K, Clifton I, Jeschke G, et al.
Mol Biosyst
. 2006 Aug;
1(4):321-4.
PMID: 16880998
Regulation of the hypoxic response in humans is regulated by the post-translational hydroxylation of hypoxia inducible transcription factor; a recombinant form of a human prolyl-4-hydroxylase (PHD2) was characterised and shown...
16.
McDonough M, Li V, Flashman E, Chowdhury R, Mohr C, Lienard B, et al.
Proc Natl Acad Sci U S A
. 2006 Jun;
103(26):9814-9.
PMID: 16782814
Cellular and physiological responses to changes in dioxygen levels in metazoans are mediated via the posttranslational oxidation of hypoxia-inducible transcription factor (HIF). Hydroxylation of conserved prolyl residues in the HIF-alpha...
17.
Murray-Rust T, Oldham N, Hewitson K, Schofield C
FEBS Lett
. 2006 Feb;
580(8):1911-8.
PMID: 16500650
In humans, many responses to hypoxia including angiogenesis and erythropoiesis are mediated by the alpha/beta-heterodimeric transcription factor hypoxia inducible factor (HIF). The stability and/or activity of human HIF-1alpha are modulated...
18.
Banerji B, Conejo-Garcia A, McNeill L, McDonough M, Buck M, Hewitson K, et al.
Chem Commun (Camb)
. 2005 Nov;
(43):5438-40.
PMID: 16261239
Cyclic beta-oxocarboxylic acids inhibit factor inhibiting hypoxia-inducible factor via ligation to the active site iron.
19.
Arulanantham H, Kershaw N, Hewitson K, Hughes C, Thirkettle J, Schofield C
J Biol Chem
. 2005 Oct;
281(1):279-87.
PMID: 16251194
(3R,5R)-Clavulanic acid, a clinically used inhibitor of serine beta-lactamases, is produced by fermentation of Streptomyces clavuligerus. The early steps in clavulanic acid biosynthesis leading to the bicyclic beta-lactam intermediate (3S,5S)-clavaminic...
20.
McDonough M, McNeill L, Tilliet M, Papamicael C, Chen Q, Banerji B, et al.
J Am Chem Soc
. 2005 May;
127(21):7680-1.
PMID: 15913349
A set of four non-heme iron(II) and 2-oxoglutarate-dependent enzymes catalyze the post-translational modification of a transcription factor, hypoxia inducible factor (HIF), that mediates the hypoxic response in animals. Hydroxylation of...