Kevin P Kenna
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Explore the profile of Kevin P Kenna including associated specialties, affiliations and a list of published articles.
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33
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2216
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Recent Articles
1.
Weinreich M, McDonough H, Yacovzada N, Magen I, Cohen Y, Harvey C, et al.
bioRxiv
. 2024 Aug;
PMID: 39091819
Time-to-event prediction is a key task for biological discovery, experimental medicine, and clinical care. This is particularly true for neurological diseases where development of reliable biomarkers is often limited by...
2.
Hop P, Lai D, Keagle P, Baron D, Kenna B, Kooyman M, et al.
Nat Genet
. 2024 Jun;
56(7):1371-1376.
PMID: 38858457
Despite substantial progress, causal variants are identified only for a minority of familial Parkinson's disease (PD) cases, leaving high-risk pathogenic variants unidentified. To identify such variants, we uniformly processed exome...
3.
Zhang S, Moll T, Rubin-Sigler J, Tu S, Li S, Yuan E, et al.
medRxiv
. 2024 Apr;
PMID: 38633814
Amyotrophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disease caused by the selective and progressive death of motor neurons (MNs). Understanding the genetic and molecular factors influencing ALS...
4.
Harvey C, Weinreich M, Lee J, Shaw A, Ferraiuolo L, Mortiboys H, et al.
Heliyon
. 2024 Feb;
10(3):e24975.
PMID: 38317984
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease involving selective vulnerability of energy-intensive motor neurons (MNs). It has been unclear whether mitochondrial function is an upstream driver or a...
5.
Zhang S, Cooper-Knock J, Weimer A, Shi M, Kozhaya L, Unutmaz D, et al.
Cell Syst
. 2022 Jun;
13(8):598-614.e6.
PMID: 35690068
The determinants of severe COVID-19 in healthy adults are poorly understood, which limits the opportunity for early intervention. We present a multiomic analysis using machine learning to characterize the genomic...
6.
Unbiased metabolome screen leads to personalized medicine strategy for amyotrophic lateral sclerosis
Boddy S, Islam M, Moll T, Kurz J, Burrows D, McGown A, et al.
Brain Commun
. 2022 Apr;
4(2):fcac069.
PMID: 35441136
Amyotrophic lateral sclerosis is a rapidly progressive neurodegenerative disease that affects 1/350 individuals in the United Kingdom. The cause of amyotrophic lateral sclerosis is unknown in the majority of cases....
7.
Eitan C, Siany A, Barkan E, Olender T, van Eijk K, Moisse M, et al.
Nat Neurosci
. 2022 Apr;
25(4):433-445.
PMID: 35361972
The noncoding genome is substantially larger than the protein-coding genome but has been largely unexplored by genetic association studies. Here, we performed region-based rare variant association analysis of >25,000 variants...
8.
Hop P, Zwamborn R, Hannon E, Shireby G, Nabais M, Walker E, et al.
Sci Transl Med
. 2022 Feb;
14(633):eabj0264.
PMID: 35196023
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an estimated heritability between 40 and 50%. DNA methylation patterns can serve as proxies of (past) exposures and disease progression,...
9.
van Rheenen W, van der Spek R, Bakker M, van Vugt J, Hop P, Zwamborn R, et al.
Nat Genet
. 2022 Feb;
54(3):361.
PMID: 35102318
No abstract available.
10.
Zhang S, Cooper-Knock J, Weimer A, Shi M, Moll T, Marshall J, et al.
Neuron
. 2022 Jan;
110(6):992-1008.e11.
PMID: 35045337
Amyotrophic lateral sclerosis (ALS) is a complex disease that leads to motor neuron death. Despite heritability estimates of 52%, genome-wide association studies (GWASs) have discovered relatively few loci. We developed...