Russell L McLaughlin
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Explore the profile of Russell L McLaughlin including associated specialties, affiliations and a list of published articles.
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65
Citations
3372
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Recent Articles
1.
Iacoangeli A, Dilliott A, Al Khleifat A, Andersen P, Basak N, Cooper-Knock J, et al.
J Neurol Neurosurg Psychiatry
. 2025 Feb;
PMID: 39947885
Background: Despite several studies suggesting a potential oligogenic risk model in amyotrophic lateral sclerosis (ALS), case-control statistical evidence implicating oligogenicity with disease risk or clinical outcomes is limited. Considering its...
2.
Shanmugam A, Merrigan M, OReilly S, Molloy A, Brody L, Hardiman O, et al.
Eur J Hum Genet
. 2025 Feb;
PMID: 39910328
While subtle yet discrete clusters of genetic identity across Ireland and Britain have been identified, their recent demographic history is unclear. Using genotype data from 6574 individuals with associated regional...
3.
Grant O, Iacoangeli A, Zwamborn R, van Rheenen W, Byrne R, van Eijk K, et al.
bioRxiv
. 2024 Dec;
PMID: 39651197
Sex is an important covariate in all genetic and epigenetic research due to its role in the incidence, progression and outcome of many phenotypic characteristics and human diseases. Amyotrophic lateral...
4.
Belbellaj W, Lona-Durazo F, Bodano C, Busseuil D, Cyr M, Fiorillo E, et al.
Sci Rep
. 2024 Oct;
14(1):24588.
PMID: 39427026
Iron is an essential mineral that supports numerous biological functions. Studies have reported associations between iron dysregulation and certain cardiovascular and neurodegenerative diseases, but the direction of influence is not...
5.
Christidi F, Kleinerova J, Tan E, Delaney S, Tacheva A, Hengeveld J, et al.
Biology (Basel)
. 2024 Jul;
13(7).
PMID: 39056697
: While frontotemporal involvement is increasingly recognized in Amyotrophic lateral sclerosis (ALS), the degeneration of limbic networks remains poorly characterized, despite growing evidence of amnestic deficits, impaired emotional processing and...
6.
Tahedl M, Tan E, Kleinerova J, Delaney S, Hengeveld J, Doherty M, et al.
Neurology
. 2024 Jun;
103(2):e209623.
PMID: 38900989
Background And Objectives: Amyotrophic lateral sclerosis (ALS) is predominantly associated with motor cortex, corticospinal tract (CST), brainstem, and spinal cord degeneration, and cerebellar involvement is much less well characterized. However,...
7.
Kleinerova J, Tahedl M, Tan E, Delaney S, Hengeveld J, Doherty M, et al.
J Neurol
. 2024 Mar;
271(6):3239-3255.
PMID: 38438819
Background: Primary lateral sclerosis (PLS) is traditionally solely associated with progressive upper motor neuron dysfunction manifesting in limb spasticity, gait impairment, bulbar symptoms and pseudobulbar affect. Recent studies have described...
8.
Ryan M, Doherty M, Al Khleifat A, Costello E, Hengeveld J, Heverin M, et al.
Neurol Genet
. 2023 Dec;
10(1):e200112.
PMID: 38149039
Background And Objectives: A hexanucleotide repeat expansion in the noncoding region of the gene is the most common genetically identifiable cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia in...
9.
Tan E, Tahedl M, Lope J, Hengeveld J, Doherty M, McLaughlin R, et al.
J Neurol
. 2023 Sep;
271(1):431-445.
PMID: 37759084
Background: Primary lateral sclerosis (PLS) is traditionally regarded as a pure upper motor neuron disorder, but recent cases series have highlighted cognitive deficits in executive and language domains. Methods: A...
10.
Tahedl M, Tan E, Chipika R, Lope J, Hengeveld J, Doherty M, et al.
Brain Behav
. 2023 Sep;
13(11):e3250.
PMID: 37694825
Background: Language deficits are cardinal manifestations of some frontotemporal dementia (FTD) phenotypes and also increasingly recognized in sporadic and familial amyotrophic lateral sclerosis (ALS). They have considerable social and quality-of-life...