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Carlos A Castaneda

Explore the profile of Carlos A Castaneda including associated specialties, affiliations and a list of published articles. Areas
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Articles 94
Citations 1959
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Recent Articles
1.
Flores E, Acharya N, Castaneda C, Sukenik S
Curr Opin Struct Biol . 2025 Feb; 91:102987. PMID: 39914051
Mutations in genomic DNA often result in single-point missense mutations in proteins. For folded proteins, the functional effect of these missense mutations can often be understood by their impact on...
2.
Rajendran A, Castaneda C
Trends Biochem Sci . 2025 Jan; 50(2):106-120. PMID: 39755440
Protein quality control (PQC) mechanisms including the ubiquitin (Ub)-proteasome system (UPS), autophagy, and chaperone-mediated refolding are essential to maintain protein homeostasis in cells. Recent studies show that these PQC mechanisms...
3.
Huang X, Lott P, Hu D, Zavala V, Jamal Z, Vidaurre T, et al.
Cancer Epidemiol Biomarkers Prev . 2024 Dec; 34(2):234-245. PMID: 39625644
Background: A substantial portion of the genetic predisposition for breast cancer is explained by multiple common genetic variants of relatively small effect. A subset of these variants, which have been...
4.
Castaneda C, Castillo M, Sanchez J, Bernabe L, Tello K, Suarez N, et al.
Ecancermedicalscience . 2024 Oct; 18:1779. PMID: 39430073
Background: CD44 is a cell-surface transmembrane glycoprotein that participates in the regulation of many cellular processes, including cell division, adhesion, migration and stem-like characteristics. CD63 is involved in the exocytosis...
5.
Valentino I, Llivicota-Guaman J, Dao T, Mulvey E, Lehman A, Galagedera S, et al.
Proc Natl Acad Sci U S A . 2024 Aug; 121(33):e2405964121. PMID: 39121161
Ubiquitination is one of the most common posttranslational modifications in eukaryotic cells. Depending on the architecture of polyubiquitin chains, substrate proteins can meet different cellular fates, but our understanding of...
6.
Castaneda C, Castillo M, Bernabe L, Sanchez J, Fassan M, Tello K, et al.
World J Gastrointest Oncol . 2024 Jul; 16(6):2487-2503. PMID: 38994161
Background: The influence of () infection and the characteristics of gastric cancer (GC) on tumor-infiltrating lymphocyte (TIL) levels has not been extensively studied. Analysis of infiltrating-immune-cell subtypes as well as...
7.
Alisafaei F, Mandal K, Saldanha R, Swoger M, Yang H, Shi X, et al.
Commun Biol . 2024 May; 7(1):658. PMID: 38811770
The cytoskeleton is a complex network of interconnected biopolymers consisting of actin filaments, microtubules, and intermediate filaments. These biopolymers work in concert to transmit cell-generated forces to the extracellular matrix...
8.
Valentino I, Llivicota-Guaman J, Dao T, Mulvey E, Lehman A, Galagedera S, et al.
bioRxiv . 2024 Apr; PMID: 38559018
Ubiquitination is one of the most common post-translational modifications in eukaryotic cells. Depending on the architecture of polyubiquitin chains, substrate proteins can meet different cellular fates, but our understanding of...
9.
Safren N, Dao T, Mohan H, Huang C, Trotter B, Castaneda C, et al.
Sci Rep . 2024 Mar; 14(1):6049. PMID: 38472280
The ubiquitin-adaptor protein UBQLN2 promotes degradation of several aggregate-prone proteins implicated in neurodegenerative diseases. Missense UBQLN2 mutations also cause X-linked amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Previously we...
10.
Dao T, Rajendran A, Galagedera S, Haws W, Castaneda C
Biophys J . 2023 Dec; 123(11):1449-1457. PMID: 38041404
Highly homologous ubiquitin-binding shuttle proteins UBQLN1, UBQLN2, and UBQLN4 differ in both their specific protein quality control functions and their propensities to localize to stress-induced condensates, cellular aggregates, and aggresomes....