Scott A Showalter
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Explore the profile of Scott A Showalter including associated specialties, affiliations and a list of published articles.
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59
Citations
832
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Recent Articles
1.
Chen W, Fraser O, George C, Showalter S
Biophys Rev (Melville)
. 2024 Nov;
5(4):041306.
PMID: 39600309
Molecular descriptions of intrinsically disordered protein regions (IDRs) are fundamental to understanding their cellular functions and regulation. NMR spectroscopy has been a leading tool in characterizing IDRs at the atomic...
2.
Mitra R, Usher E, Dedeoglu S, Crotteau M, Fraser O, Yennawar N, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(49):e2409139121.
PMID: 39589885
Intrinsically disordered protein regions (IDRs) are well established as contributors to intermolecular interactions and the formation of biomolecular condensates. In particular, RNA-binding proteins (RBPs) often harbor IDRs in addition to...
3.
Dewing S, Phan T, Kraft E, Mittal J, Showalter S
J Phys Chem B
. 2024 Oct;
128(43):10636-10649.
PMID: 39437158
Acetylation of the histone H4 tail (H4Kac) has been established as a significant regulator of chromatin architecture and accessibility; however, the molecular mechanisms that underlie these observations remain elusive. Here,...
4.
Mitra R, Usher E, Dedeoglu S, Crotteau M, Fraser O, Yennawar N, et al.
bioRxiv
. 2024 Jun;
PMID: 38915483
Intrinsically disordered protein regions (IDRs) are well-established as contributors to intermolecular interactions and the formation of biomolecular condensates. In particular, RNA-binding proteins (RBPs) often harbor IDRs in addition to folded...
5.
Namitz K, Showalter S, Cosgrove M
J Biol Chem
. 2023 Sep;
299(10):105204.
PMID: 37660926
Enzymes that regulate the degree of histone H3 lysine 4 (H3K4) methylation are crucial for proper cellular differentiation and are frequently mutated in cancer. The Mixed lineage leukemia (MLL) family...
6.
Fraser O, Namitz K, Showalter S
Methods
. 2023 Jul;
218:72-83.
PMID: 37524235
Post-translational modifications (PTMs) are reversible chemical modifications that can modulate protein structure and function. Methylation and acetylation are two such PTMs with integral and well-characterized biological roles, including modulation of...
7.
Fraser O, Dewing S, Usher E, George C, Showalter S
Front Mol Biosci
. 2023 Jan;
9:1074743.
PMID: 36685286
Intrinsically disordered proteins are frequent targets for functional regulation through post-translational modification due to their high accessibility to modifying enzymes and the strong influence of changes in primary structure on...
8.
Usher E, Showalter S
J Biol Chem
. 2022 Oct;
298(12):102623.
PMID: 36272648
The pancreatic and duodenal homeobox 1 (PDX1) is a central regulator of glucose-dependent transcription of insulin in pancreatic β cells. PDX1 transcription factor activity is integral to the development and...
9.
Usher E, Namitz K, Cosgrove M, Showalter S
Biophys J
. 2021 Sep;
120(21):4710-4721.
PMID: 34592262
Post-translational modification (PTM) of proteins is of critical importance to the regulation of many cellular processes in eukaryotic organisms. One of the most well-studied protein PTMs is methylation, wherein an...
10.
Prieto V, Namitz K, Showalter S
J Phys Chem B
. 2021 Sep;
125(39):10917-10927.
PMID: 34550709
Intrinsically disordered protein (IDP) sequences often contain a high proportion of charged residues in conjunction with their high degree of hydrophilicity and solvation. For high net charge IDPs, long-range electrostatic...