Kevin C H Ha
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Explore the profile of Kevin C H Ha including associated specialties, affiliations and a list of published articles.
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22
Citations
1123
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Recent Articles
1.
Ni Z, Ahmed N, Nabeel-Shah S, Guo X, Pu S, Song J, et al.
Nucleic Acids Res
. 2024 Apr;
52(8):4483-4501.
PMID: 38587191
Messenger RNA precursors (pre-mRNA) generally undergo 3' end processing by cleavage and polyadenylation (CPA), which is specified by a polyadenylation site (PAS) and adjacent RNA sequences and regulated by a...
2.
Song J, Nabeel-Shah S, Pu S, Lee H, Braunschweig U, Ni Z, et al.
Mol Cell
. 2022 Aug;
82(17):3135-3150.e9.
PMID: 35914531
Alternative polyadenylation (APA) enhances gene regulatory potential by increasing the diversity of mRNA transcripts. 3' UTR shortening through APA correlates with enhanced cellular proliferation and is a widespread phenomenon in...
3.
Differential contribution of transcriptomic regulatory layers in the definition of neuronal identity
Ha K, Sterne-Weiler T, Morris Q, Weatheritt R, Blencowe B
Nat Commun
. 2021 Jan;
12(1):335.
PMID: 33436550
Previous transcriptomic profiling studies have typically focused on separately analyzing mRNA expression, alternative splicing and alternative polyadenylation differences between cell and tissue types. However, the relative contribution of these three...
4.
Gonatopoulos-Pournatzis T, Aregger M, Brown K, Farhangmehr S, Braunschweig U, Ward H, et al.
Nat Biotechnol
. 2020 Apr;
38(5):638-648.
PMID: 32249828
Systematic mapping of genetic interactions (GIs) and interrogation of the functions of sizable genomic segments in mammalian cells represent important goals of biomedical research. To advance these goals, we present...
5.
Rodrigues D, Mufteev M, Weatheritt R, Djuric U, Ha K, Ross P, et al.
Cell Rep
. 2020 Mar;
30(12):4179-4196.e11.
PMID: 32209477
Regulation of translation during human development is poorly understood, and its dysregulation is associated with Rett syndrome (RTT). To discover shifts in mRNA ribosomal engagement (RE) during human neurodevelopment, we...
6.
Sterne-Weiler T, Weatheritt R, Best A, Ha K, Blencowe B
Mol Cell
. 2018 Sep;
72(1):187-200.e6.
PMID: 30220560
Alternative splicing (AS) is a widespread process underlying the generation of transcriptomic and proteomic diversity and is frequently misregulated in human disease. Accordingly, an important goal of biomedical research is...
7.
Ha K, Blencowe B, Morris Q
Genome Biol
. 2018 Mar;
19(1):45.
PMID: 29592814
Alternative polyadenylation (APA) affects most mammalian genes. The genome-wide investigation of APA has been hampered by an inability to reliably profile it using conventional RNA-seq. We describe 'Quantification of APA'...
8.
Tapial J, Ha K, Sterne-Weiler T, Gohr A, Braunschweig U, Hermoso-Pulido A, et al.
Genome Res
. 2017 Sep;
27(10):1759-1768.
PMID: 28855263
Alternative splicing (AS) generates remarkable regulatory and proteomic complexity in metazoans. However, the functions of most AS events are not known, and programs of regulated splicing remain to be identified....
9.
Dang H, Takai A, Forgues M, Pomyen Y, Mou H, Xue W, et al.
Cancer Cell
. 2017 Jul;
32(1):101-114.e8.
PMID: 28697339
Global transcriptomic imbalance is a ubiquitous feature associated with cancer, including hepatocellular carcinoma (HCC). Analyses of 1,225 clinical HCC samples revealed that a large numbers of RNA binding proteins (RBPs)...
10.
Cook K, Vembu S, Ha K, Zheng H, Laverty K, Hughes T, et al.
Methods
. 2017 Jun;
126:18-28.
PMID: 28651966
RNA-binding proteins recognize RNA sequences and structures, but there is currently no systematic and accurate method to derive large (>12base) motifs de novo that reflect a combination of intrinsic preference...