Benjamin J Blencowe
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Explore the profile of Benjamin J Blencowe including associated specialties, affiliations and a list of published articles.
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Articles
156
Citations
17749
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Recent Articles
1.
CDC40 suppression induces CDCA5 splicing defects and anti-proliferative effects in lung cancer cells
Hu D, Theriault B, Talebian V, Hoffer L, Owen J, Lim J, et al.
Sci Rep
. 2025 Jan;
15(1):315.
PMID: 39747150
High mortality and low response rates in lung cancer patients call for novel therapeutic targets. Data mining of whole-genome genetic dependency screens suggest Cell Division Cycle 40 (CDC40) to be...
2.
Nabeel-Shah S, Pu S, Burns J, Braunschweig U, Ahmed N, Burke G, et al.
Mol Cell
. 2024 Sep;
84(19):3810-3825.e10.
PMID: 39303720
Cys2-His2 zinc-finger proteins (C2H2-ZNFs) constitute the largest class of DNA-binding transcription factors (TFs) yet remain largely uncharacterized. Although certain family members, e.g., GTF3A, have been shown to bind both DNA...
3.
Nabeel-Shah S, Pu S, Burke G, Ahmed N, Braunschweig U, Farhangmehr S, et al.
Genome Biol
. 2024 Sep;
25(1):246.
PMID: 39300486
Background: N6-methyladenosine (m6A), the most abundant internal modification on eukaryotic mRNA, and N6, 2'-O-dimethyladenosine (m6Am), are epitranscriptomic marks that function in multiple aspects of posttranscriptional regulation. Fat mass and obesity-associated...
4.
Lim J, Vining K, Mooney D, Blencowe B
Proc Natl Acad Sci U S A
. 2024 Jul;
121(32):e2404146121.
PMID: 39074278
Cell-matrix interactions in 3D environments significantly differ from those in 2D cultures. As such, mechanisms of mechanotransduction in 2D cultures are not necessarily applicable to cell-encapsulating hydrogels that resemble features...
5.
Best A, Braunschweig U, Wu M, Farhangmehr S, Pasculescu A, Lim J, et al.
Nat Commun
. 2024 Jul;
15(1):6328.
PMID: 39068192
Disruption of alternative splicing frequently causes or contributes to human diseases and disorders. Consequently, there is a need for efficient and sensitive reporter assays capable of screening chemical libraries for...
6.
Li J, Taipale M, Blencowe B
Mol Cell
. 2024 Jun;
84(13):2573-2589.e5.
PMID: 38917795
Efficient targeted control of splicing is a major goal of functional genomics and therapeutic applications. Guide (g)RNA-directed, deactivated (d)Cas CRISPR enzymes fused to splicing effectors represent a promising strategy due...
7.
Wong R, Balachandran A, Cheung P, Cheng R, Pan Q, Stoilov P, et al.
PLoS Pathog
. 2024 Apr;
20(4):e1012155.
PMID: 38593115
[This corrects the article DOI: 10.1371/journal.ppat.1008307.].
8.
Ni Z, Ahmed N, Nabeel-Shah S, Guo X, Pu S, Song J, et al.
Nucleic Acids Res
. 2024 Apr;
52(8):4483-4501.
PMID: 38587191
Messenger RNA precursors (pre-mRNA) generally undergo 3' end processing by cleavage and polyadenylation (CPA), which is specified by a polyadenylation site (PAS) and adjacent RNA sequences and regulated by a...
9.
Roth J, Braunschweig U, Wu M, Li J, Lin Z, Larsen B, et al.
Mol Cell
. 2023 Dec;
83(23):4222-4238.e10.
PMID: 38065061
Alternative splicing significantly expands biological complexity, particularly in the vertebrate nervous system. Increasing evidence indicates that developmental and tissue-dependent alternative exons often control protein-protein interactions; yet, only a minor fraction...
10.
Cui H, Diedrich J, Wu D, Lim J, Nottingham R, Moresco J, et al.
Nat Cell Biol
. 2023 May;
25(7):1073.
PMID: 37237245
No abstract available.