Syed Nabeel-Shah
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Explore the profile of Syed Nabeel-Shah including associated specialties, affiliations and a list of published articles.
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26
Citations
377
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Recent Articles
1.
Lee E, Smith H, Wang Y, Ihn S, Scalize de Oliveira L, Kejiou N, et al.
Life Sci Alliance
. 2024 Dec;
8(2).
PMID: 39626965
In humans, misprocessed mRNAs containing intact 5' Splice Site (5'SS) motifs are nuclear retained and targeted for decay by ZFC3H1, a component of the Poly(A) Exosome Targeting complex, and U1-70K,...
2.
Nabeel-Shah S, Pu S, Burns J, Braunschweig U, Ahmed N, Burke G, et al.
Mol Cell
. 2024 Sep;
84(19):3810-3825.e10.
PMID: 39303720
Cys2-His2 zinc-finger proteins (C2H2-ZNFs) constitute the largest class of DNA-binding transcription factors (TFs) yet remain largely uncharacterized. Although certain family members, e.g., GTF3A, have been shown to bind both DNA...
3.
Nabeel-Shah S, Pu S, Burke G, Ahmed N, Braunschweig U, Farhangmehr S, et al.
Genome Biol
. 2024 Sep;
25(1):246.
PMID: 39300486
Background: N6-methyladenosine (m6A), the most abundant internal modification on eukaryotic mRNA, and N6, 2'-O-dimethyladenosine (m6Am), are epitranscriptomic marks that function in multiple aspects of posttranscriptional regulation. Fat mass and obesity-associated...
4.
Ni Z, Ahmed N, Nabeel-Shah S, Guo X, Pu S, Song J, et al.
Nucleic Acids Res
. 2024 Apr;
52(8):4483-4501.
PMID: 38587191
Messenger RNA precursors (pre-mRNA) generally undergo 3' end processing by cleavage and polyadenylation (CPA), which is specified by a polyadenylation site (PAS) and adjacent RNA sequences and regulated by a...
5.
Nabeel-Shah S, Greenblatt J
Bio Protoc
. 2023 Jun;
13(11):e4688.
PMID: 37323634
Individual nucleotide resolution UV cross-linking and immunoprecipitation followed by high-throughput sequencing (iCLIP-seq) is a powerful technique that is used to identify RNA-binding proteins' (RBP) binding sites on target RNAs and...
6.
Nabeel-Shah S, Garg J, Ashraf K, Jeyapala R, Lee H, Petrova A, et al.
Epigenetics Chromatin
. 2023 Apr;
16(1):10.
PMID: 37024975
Background: Eukaryotic cells can rapidly adjust their transcriptional profile in response to molecular needs. Such dynamic regulation is, in part, achieved through epigenetic modifications and selective incorporation of histone variants...
7.
Ray D, Laverty K, Jolma A, Nie K, Samson R, Pour S, et al.
Sci Rep
. 2023 Mar;
13(1):5238.
PMID: 37002329
Thousands of RNA-binding proteins (RBPs) crosslink to cellular mRNA. Among these are numerous unconventional RBPs (ucRBPs)-proteins that associate with RNA but lack known RNA-binding domains (RBDs). The vast majority of...
8.
Segal D, Maier S, Mastromarco G, Qian W, Nabeel-Shah S, Lee H, et al.
Mol Cell
. 2023 Mar;
83(6):974-993.e15.
PMID: 36931259
14-3-3 proteins are highly conserved regulatory proteins that interact with hundreds of structurally diverse clients and act as central hubs of signaling networks. However, how 14-3-3 paralogs differ in specificity...
9.
Song J, Nabeel-Shah S, Pu S, Lee H, Braunschweig U, Ni Z, et al.
Mol Cell
. 2022 Aug;
82(17):3135-3150.e9.
PMID: 35914531
Alternative polyadenylation (APA) enhances gene regulatory potential by increasing the diversity of mRNA transcripts. 3' UTR shortening through APA correlates with enhanced cellular proliferation and is a widespread phenomenon in...
10.
Han H, Best A, Braunschweig U, Mikolajewicz N, Li J, Roth J, et al.
Mol Cell
. 2022 Aug;
82(16):2982-2999.e14.
PMID: 35914530
Alternative splicing (AS) is a critical regulatory layer; yet, factors controlling functionally coordinated splicing programs during developmental transitions are poorly understood. Here, we employ a screening strategy to identify factors...