Robert J Weatheritt
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Explore the profile of Robert J Weatheritt including associated specialties, affiliations and a list of published articles.
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40
Citations
3981
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Recent Articles
1.
Chambers C, Watakul S, Schofield P, Howell A, Zhu J, Tran A, et al.
Sci Adv
. 2025 Mar;
11(11):eadq4416.
PMID: 40073121
Pancreatic cancer (PC) is a highly metastatic malignancy. More than 80% of patients with PC present with advanced-stage disease, preventing potentially curative surgery. The neuropeptide Y (NPY) system, best known...
2.
Kjer-Hansen P, Phan T, Weatheritt R
Nat Rev Drug Discov
. 2024 Sep;
23(10):759-779.
PMID: 39232238
Most protein-coding genes produce multiple protein isoforms; however, these isoforms are commonly neglected in drug discovery. The expression of protein isoforms can be specific to a disease, tissue and/or developmental...
3.
Xiao M, Damodaran A, Kumari B, Dickson E, Xing K, On T, et al.
Mol Cell
. 2024 Jun;
84(13):2553-2572.e19.
PMID: 38917794
CRISPR-Cas technology has transformed functional genomics, yet understanding of how individual exons differentially shape cellular phenotypes remains limited. Here, we optimized and conducted massively parallel exon deletion and splice-site mutation...
4.
Roth J, Braunschweig U, Wu M, Li J, Lin Z, Larsen B, et al.
Mol Cell
. 2023 Dec;
83(23):4222-4238.e10.
PMID: 38065061
Alternative splicing significantly expands biological complexity, particularly in the vertebrate nervous system. Increasing evidence indicates that developmental and tissue-dependent alternative exons often control protein-protein interactions; yet, only a minor fraction...
5.
Kjer-Hansen P, Weatheritt R
Nat Struct Mol Biol
. 2023 Nov;
30(12):1844-1856.
PMID: 38036695
Alternative splicing affects more than 95% of multi-exon genes in the human genome. These changes affect the proteome in a myriad of ways. Here, we review our understanding of the...
6.
Sinitcyn P, Richards A, Weatheritt R, Brademan D, Marx H, Shishkova E, et al.
Nat Biotechnol
. 2023 Mar;
41(12):1776-1786.
PMID: 36959352
An average shotgun proteomics experiment detects approximately 10,000 human proteins from a single sample. However, individual proteins are typically identified by peptide sequences representing a small fraction of their total...
7.
Skvortsova K, Bertrand S, Voronov D, Duckett P, Ross S, Magri M, et al.
Sci Adv
. 2022 Dec;
8(48):eabn2258.
PMID: 36459547
DNA methylation [5-methylcytosine (5mC)] is a repressive gene-regulatory mark required for vertebrate embryogenesis. Genomic 5mC is tightly regulated through the action of DNA methyltransferases, which deposit 5mC, and ten-eleven translocation...
8.
Bartonicek N, Rouet R, Warren J, Loetsch C, Rodriguez G, Walters S, et al.
Nature
. 2022 Aug;
608(7924):757-765.
PMID: 35948641
The notion that mobile units of nucleic acid known as transposable elements can operate as genomic controlling elements was put forward over six decades ago. However, it was not until...
9.
Han H, Best A, Braunschweig U, Mikolajewicz N, Li J, Roth J, et al.
Mol Cell
. 2022 Aug;
82(16):2982-2999.e14.
PMID: 35914530
Alternative splicing (AS) is a critical regulatory layer; yet, factors controlling functionally coordinated splicing programs during developmental transitions are poorly understood. Here, we employ a screening strategy to identify factors...
10.
Barutcu A, Wu M, Braunschweig U, Dyakov B, Luo Z, Turner K, et al.
Mol Cell
. 2022 Feb;
82(5):1035-1052.e9.
PMID: 35182477
The nucleus is highly compartmentalized through the formation of distinct classes of membraneless domains. However, the composition and function of many of these structures are not well understood. Using APEX2-mediated...