Kerstin Stemmer
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Explore the profile of Kerstin Stemmer including associated specialties, affiliations and a list of published articles.
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59
Citations
1992
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Recent Articles
11.
Novikoff A, OBrien S, Bernecker M, Grandl G, Kleinert M, Knerr P, et al.
Mol Metab
. 2021 Feb;
49:101181.
PMID: 33556643
Objective: We assessed the spatiotemporal GLP-1 and GIP receptor signaling, trafficking, and recycling dynamics of GIPR mono-agonists, GLP-1R mono-agonists including semaglutide, and GLP-1/GIP dual-agonists MAR709 and tirzepatide. Methods: Receptor G...
12.
Sachs S, Niu L, Geyer P, Jall S, Kleinert M, Feuchtinger A, et al.
Diabetes Obes Metab
. 2020 Oct;
23(1):195-207.
PMID: 33001570
Aims: Unimolecular peptides targeting the receptors for glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) (GLP-1/GIP co-agonist) have been shown to outperform each single peptide in the treatment of obesity...
13.
Schriever S, Kabra D, Pfuhlmann K, Baumann P, Baumgart E, Nagler J, et al.
J Clin Invest
. 2020 Aug;
130(11):6093-6108.
PMID: 32780722
Recent genome-wide association studies (GWAS) identified DUSP8, encoding a dual-specificity phosphatase targeting mitogen-activated protein kinases, as a type 2 diabetes (T2D) risk gene. Here, we reveal that Dusp8 is a...
14.
Seitz S, Kwon Y, Hartleben G, Julg J, Sekar R, Krahmer N, et al.
Nat Metab
. 2020 Jul;
1(10):1009-1026.
PMID: 32694843
Non-alcoholic fatty liver disease (NAFLD) represents a key feature of obesity-related type 2 diabetes with increasing prevalence worldwide. To our knowledge, no treatment options are available to date, paving the...
15.
Stemmer K, Finan B, DiMarchi R, Tschop M, Muller T
Adv Drug Deliv Rev
. 2020 Jun;
159:34-53.
PMID: 32485206
Derangements in triglyceride and cholesterol metabolism (dyslipidemia) are major risk factors for the development of cardiovascular diseases in obese and type-2 diabetic (T2D) patients. An emerging class of glucagon-like peptide-1...
16.
Fischer K, Fenzl A, Liu D, Dyar K, Kleinert M, Brielmeier M, et al.
Nat Commun
. 2020 May;
11(1):2306.
PMID: 32385399
During β-adrenergic stimulation of brown adipose tissue (BAT), p38 phosphorylates the activating transcription factor 2 (ATF2) which then translocates to the nucleus to activate the expression of Ucp1 and Pgc-1α....
17.
Jall S, De Angelis M, Lundsgaard A, Fritzen A, Nicolaisen T, Klein A, et al.
Diabetologia
. 2020 Mar;
63(6):1236-1247.
PMID: 32140744
Aims/hypothesis: Treatment with the α3β4 nicotinic acetylcholine receptor (nAChR) agonist, 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP), improves glucose tolerance in diet-induced obese (DIO) mice, but the physiological and molecular mechanisms are unknown. Methods:...
18.
Stemmer K, Muller T, DiMarchi R, Pfluger P, Tschop M
J Clin Invest
. 2019 Aug;
129(10):4058-4071.
PMID: 31380808
The metabolic syndrome (MetS) encompasses medical conditions such as obesity, hyperglycemia, high blood pressure, and dyslipidemia that are major drivers for the ever-increasing prevalence of type 2 diabetes, cardiovascular diseases,...
19.
Muller G, Herling A, Stemmer K, Lechner A, Tschop M
Am J Physiol Endocrinol Metab
. 2019 May;
317(2):E212-E233.
PMID: 31039006
To study the possibility that certain components of eukaryotic plasma membranes are released under certain (patho)physiological conditions, a chip-based sensor was developed for the detection of cell surface proteins, which...
20.
Bastek H, Zubel T, Stemmer K, Mangerich A, Beneke S, Dietrich D
Toxicology
. 2019 Apr;
420:29-38.
PMID: 30940547
Aristolochic acid (AA) dependent human nephropathy results either from environmental exposure to Aristolochiaceae plant subspecies or their use in traditional phytotherapy. The toxic components are structurally related nitrophenanthrene carboxylic acids,...