Kenyi Saito-Diaz
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Explore the profile of Kenyi Saito-Diaz including associated specialties, affiliations and a list of published articles.
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19
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528
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Recent Articles
1.
Saito-Diaz K, Saini T, Patel A, James C, Thomas K, Knight T, et al.
bioRxiv
. 2024 Nov;
PMID: 39605577
The extracellular matrix (ECM) is a mixture of glycoproteins and fibrous proteins that provide the biophysical properties necessary to maintain cellular homeostasis. ECM integrity is of particular importance during development,...
2.
Saito-Diaz K, Dietrich P, Saini T, Rashid M, Wu H, Ishan M, et al.
Sci Transl Med
. 2024 Nov;
16(774):eadq2418.
PMID: 39565876
The peripheral nervous system (PNS) is essential for proper body function. A high percentage of the world's population suffers from nerve degeneration or peripheral nerve damage. Despite this, there are...
3.
Wu H, Saito-Diaz K, Huang C, McAlpine J, Seo D, Magruder D, et al.
Cell Stem Cell
. 2024 Apr;
31(5):734-753.e8.
PMID: 38608707
Autonomic parasympathetic neurons (parasymNs) control unconscious body responses, including "rest-and-digest." ParasymN innervation is important for organ development, and parasymN dysfunction is a hallmark of autonomic neuropathy. However, parasymN function and...
4.
Zeltner N, Wu H, Saito-Diaz K, Sun X, Song M, Saini T, et al.
Res Sq
. 2024 Apr;
PMID: 38562819
The technology of human pluripotent stem cell (hPSC)-based 3D organoid/assembloid cultures has become a powerful tool for the study of human embryonic development, disease modeling and drug discovery in recent...
5.
Saito-Diaz K, James C, Patel A, Zeltner N
Front Cell Dev Biol
. 2023 May;
11:1101423.
PMID: 37206924
Sensory neurons (SNs) detect a wide range of information from the body and the environment that is critical for homeostasis. There are three main subtypes of SNs: nociceptors, mechanoreceptors, and...
6.
Saito-Diaz K, Dietrich P, Wu H, Sun X, Patel A, Wzientek C, et al.
bioRxiv
. 2023 Mar;
PMID: 36993570
The peripheral nervous system (PNS) is essential for proper body function. A high percentage of the population suffer nerve degeneration or peripheral damage. For example, over 40% of patients with...
7.
Kassel S, Hanson A, Benchabane H, Saito-Diaz K, Cabel C, Goldsmith L, et al.
Sci Signal
. 2023 Feb;
16(771):eabn8372.
PMID: 36749823
The Wnt-β-catenin signal transduction pathway is essential for embryonic development and adult tissue homeostasis. Wnt signaling converts TCF from a transcriptional repressor to an activator in a process facilitated by...
8.
Norepinephrine transporter defects lead to sympathetic hyperactivity in Familial Dysautonomia models
Wu H, Yu W, Saito-Diaz K, Huang C, Carey J, Lefcort F, et al.
Nat Commun
. 2022 Nov;
13(1):7032.
PMID: 36396637
Familial dysautonomia (FD), a rare neurodevelopmental and neurodegenerative disorder affects the sympathetic and sensory nervous system. Although almost all patients harbor a mutation in ELP1, it remains unresolved exactly how...
9.
Saito-Diaz K, Zeltner N
STAR Protoc
. 2022 Mar;
3(2):101187.
PMID: 35330962
Human pluripotent stem cells (hPSCs) show promise for studying diseases affecting cell populations that are not easily available, including sensory neurons (SNs). Here, we present a differentiation protocol in chemically...
10.
Saito-Diaz K, Street J, Ulrichs H, Zeltner N
Stem Cell Reports
. 2021 Feb;
16(3):446-457.
PMID: 33545066
The three peripheral sensory neuron (SN) subtypes, nociceptors, mechanoreceptors, and proprioceptors, localize to dorsal root ganglia and convey sensations such as pain, temperature, pressure, and limb movement/position. Despite previous reports,...