Hsueh-Fu Wu
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Explore the profile of Hsueh-Fu Wu including associated specialties, affiliations and a list of published articles.
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14
Citations
75
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Recent Articles
1.
Saito-Diaz K, Dietrich P, Saini T, Rashid M, Wu H, Ishan M, et al.
Sci Transl Med
. 2024 Nov;
16(774):eadq2418.
PMID: 39565876
The peripheral nervous system (PNS) is essential for proper body function. A high percentage of the world's population suffers from nerve degeneration or peripheral nerve damage. Despite this, there are...
2.
Wu H, Ishan M, Rashid M, Liu H, Zeltner N
Bio Protoc
. 2024 Nov;
14(21):e5101.
PMID: 39525966
The parasympathetic nervous system is essential for salivary gland development and functionality. Parasympathetic neuron (parasymN) innervation is the main neural network that controls salivary secretion. Therefore, an exclusive model to...
3.
Wu H, Hamilton C, Porritt H, Winbo A, Zeltner N
J Physiol
. 2024 Sep;
PMID: 39235952
Throughout our lifetime the heart executes cycles of contraction and relaxation to meet the body's ever-changing metabolic needs. This vital function is continuously regulated by the autonomic nervous system. Cardiovascular...
4.
Wu H, Saito-Diaz K, Huang C, McAlpine J, Seo D, Magruder D, et al.
Cell Stem Cell
. 2024 Apr;
31(5):734-753.e8.
PMID: 38608707
Autonomic parasympathetic neurons (parasymNs) control unconscious body responses, including "rest-and-digest." ParasymN innervation is important for organ development, and parasymN dysfunction is a hallmark of autonomic neuropathy. However, parasymN function and...
5.
Zeltner N, Wu H, Saito-Diaz K, Sun X, Song M, Saini T, et al.
Res Sq
. 2024 Apr;
PMID: 38562819
The technology of human pluripotent stem cell (hPSC)-based 3D organoid/assembloid cultures has become a powerful tool for the study of human embryonic development, disease modeling and drug discovery in recent...
6.
Wu H, Art J, Saini T, Zeltner N
STAR Protoc
. 2024 Mar;
5(2):102970.
PMID: 38517897
Assessing the development and function of the sympathetic nervous system in diseases on a large scale is challenging. Here, we present a protocol to generate human pluripotent stem cell (hPSC)-derived...
7.
Wu H, Huang C, Art J, Liu H, Hart G, Zeltner N
Front Neurosci
. 2023 May;
17:1137847.
PMID: 37229433
O-GlcNAcylation is a post-translational modification (PTM) that regulates a wide range of cellular functions and has been associated with multiple metabolic diseases in various organs. The sympathetic nervous system (SNS)...
8.
Huang C, Rust N, Wu H, Yin A, Zeltner N, Yin H, et al.
Alzheimers Dement
. 2023 Apr;
19(11):4872-4885.
PMID: 37037474
Introduction: Sporadic Alzheimer's disease (sAD) is the leading type of dementia. Brain glucose hypometabolism, along with decreased O-GlcNAcylation levels, occurs before the onset of symptoms and correlates with pathogenesis. Heretofore,...
9.
Saito-Diaz K, Dietrich P, Wu H, Sun X, Patel A, Wzientek C, et al.
bioRxiv
. 2023 Mar;
PMID: 36993570
The peripheral nervous system (PNS) is essential for proper body function. A high percentage of the population suffer nerve degeneration or peripheral damage. For example, over 40% of patients with...
10.
Norepinephrine transporter defects lead to sympathetic hyperactivity in Familial Dysautonomia models
Wu H, Yu W, Saito-Diaz K, Huang C, Carey J, Lefcort F, et al.
Nat Commun
. 2022 Nov;
13(1):7032.
PMID: 36396637
Familial dysautonomia (FD), a rare neurodevelopmental and neurodegenerative disorder affects the sympathetic and sensory nervous system. Although almost all patients harbor a mutation in ELP1, it remains unresolved exactly how...