Katherine R Mattaini
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Explore the profile of Katherine R Mattaini including associated specialties, affiliations and a list of published articles.
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12
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2627
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Recent Articles
1.
Mattaini K, Sullivan M, Lau A, Fiske B, Bronson R, Vander Heiden M
BMC Cancer
. 2019 Jul;
19(1):723.
PMID: 31331318
Background: Copy number gain of the D-3-phosphoglycerate dehydrogenase (PHGDH) gene, which encodes the first enzyme in serine biosynthesis, is found in some human cancers including a subset of melanomas. Methods:...
2.
Sullivan M, Mattaini K, Dennstedt E, Nguyen A, Sivanand S, Reilly M, et al.
Cell Metab
. 2019 Mar;
29(6):1410-1421.e4.
PMID: 30905671
Tumors exhibit altered metabolism compared to normal tissues. Many cancers upregulate expression of serine synthesis pathway enzymes, and some tumors exhibit copy-number gain of the gene encoding the first enzyme...
3.
Mattaini K, Sullivan M, Vander Heiden M
J Cell Biol
. 2016 Jul;
214(3):249-57.
PMID: 27458133
Serine metabolism is frequently dysregulated in cancers; however, the benefit that this confers to tumors remains controversial. In many cases, extracellular serine alone is sufficient to support cancer cell proliferation,...
4.
Mattaini K, Brignole E, Kini M, Davidson S, Fiske B, Drennan C, et al.
Cancer Metab
. 2015 May;
3:5.
PMID: 25926973
Background: The gene encoding the serine biosynthesis pathway enzyme PHGDH is located in a region of focal genomic copy number gain in human cancers. Cells with PHGDH amplification are dependent...
5.
Fan J, Teng X, Liu L, Mattaini K, Looper R, Vander Heiden M, et al.
ACS Chem Biol
. 2014 Nov;
10(2):510-6.
PMID: 25406093
Human d-3-phosphoglycerate dehydrogenase (PHGDH), the first enzyme in the serine biosynthetic pathway, is genomically amplified in tumors including breast cancer and melanoma. In PHGDH-amplified cancer cells, knockdown of PHGDH is...
6.
Alsarraj J, Faraji F, Geiger T, Mattaini K, Williams M, Wu J, et al.
PLoS One
. 2013 Nov;
8(11):e80746.
PMID: 24260471
Recent studies suggest that BET inhibitors are effective anti-cancer therapeutics. Here we show that BET inhibitors are effective against murine primary mammary tumors, but not pulmonary metastases. BRD4, a target...
7.
Mattaini K, Vander Heiden M
Science
. 2012 Aug;
337(6097):925-6.
PMID: 22923571
No abstract available.
8.
Anastasiou D, Yu Y, Israelsen W, Jiang J, Boxer M, Hong B, et al.
Nat Chem Biol
. 2012 Aug;
8(10):839-47.
PMID: 22922757
Cancer cells engage in a metabolic program to enhance biosynthesis and support cell proliferation. The regulatory properties of pyruvate kinase M2 (PKM2) influence altered glucose metabolism in cancer. The interaction...
9.
Metallo C, Gameiro P, Bell E, Mattaini K, Yang J, Hiller K, et al.
Nature
. 2011 Nov;
481(7381):380-4.
PMID: 22101433
Acetyl coenzyme A (AcCoA) is the central biosynthetic precursor for fatty-acid synthesis and protein acetylation. In the conventional view of mammalian cell metabolism, AcCoA is primarily generated from glucose-derived pyruvate...
10.
Mullarky E, Mattaini K, Vander Heiden M, Cantley L, Locasale J
Pigment Cell Melanoma Res
. 2011 Oct;
24(6):1112-5.
PMID: 21981974
The metabolic requirements of cancer cells differ from that of their normal counterparts. To support their proliferation, cancer cells switch to a fermentative metabolism that is thought to support biomass...