Lewis C Cantley
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Explore the profile of Lewis C Cantley including associated specialties, affiliations and a list of published articles.
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414
Citations
65424
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Recent Articles
1.
He X, Wang Q, Cheng X, Wang W, Li Y, Nan Y, et al.
Cell
. 2025 Mar;
PMID: 40023152
Vitamin C (vitC) is essential for health and shows promise in treating diseases like cancer, yet its mechanisms remain elusive. Here, we report that vitC directly modifies lysine residues to...
2.
Horne C, Dite T, Young S, Mather L, Dagley L, Johnson J, et al.
Proc Natl Acad Sci U S A
. 2025 Feb;
122(8):e2420961122.
PMID: 39964718
Protein Serine Kinase H1 (PSKH1) was recently identified as a crucial factor in kidney development and is overexpressed in prostate, lung, and kidney cancers. However, little is known about PSKH1...
3.
OBoyle B, Yeung W, Lu J, Katiyar S, Yaron-Barir T, Johnson J, et al.
bioRxiv
. 2025 Jan;
PMID: 39868133
Bacterial serine-threonine protein kinases (STKs) regulate diverse cellular processes associated with cell growth, virulence, and pathogenicity. They are evolutionarily related to the druggable eukaryotic STKs. However, an incomplete knowledge of...
4.
Hillis A, Tamir T, Perry G, Asara J, Johnson J, Yaron T, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(47):e2413837121.
PMID: 39536083
Tyrosine phosphorylation of metabolic enzymes is an evolutionarily conserved posttranslational modification that facilitates rapid and reversible modulation of enzyme activity, localization, or function. Despite the high abundance of tyrosine phosphorylation...
5.
Wu Y, Foollee A, Chan A, Hille S, Hauke J, Challis M, et al.
Nat Commun
. 2024 Sep;
15(1):8390.
PMID: 39333498
The peptide hormone glucagon is a fundamental metabolic regulator that is also being considered as a pharmacotherapeutic option for obesity and type 2 diabetes. Despite this, we know very little...
6.
Liu J, Cao S, Imbach K, Gritsenko M, Lih T, Kyle J, et al.
Cancer Cell
. 2024 Jul;
42(7):1217-1238.e19.
PMID: 38981438
Although genomic anomalies in glioblastoma (GBM) have been well studied for over a decade, its 5-year survival rate remains lower than 5%. We seek to expand the molecular landscape of...
7.
Gassaway B, Huttlin E, Huntsman E, Yaron-Barir T, Johnson J, Kurmi K, et al.
Mol Cell Proteomics
. 2024 Jun;
23(7):100801.
PMID: 38880243
T cell activation is a complex biological process of naive cells maturing into effector cells. Proteomic and phospho-proteomic approaches have provided critical insights into this process, yet it is not...
8.
Sinha N, McKenney C, Yeow Z, Li J, Nam K, Yaron-Barir T, et al.
Cell
. 2024 Jun;
187(14):3652-3670.e40.
PMID: 38843833
While ultraviolet (UV) radiation damages DNA, eliciting the DNA damage response (DDR), it also damages RNA, triggering transcriptome-wide ribosomal collisions and eliciting a ribotoxic stress response (RSR). However, the relative...
9.
Klomp J, Diehl J, Klomp J, Edwards A, Yang R, Morales A, et al.
Science
. 2024 Jun;
384(6700):eadk0850.
PMID: 38843329
To delineate the mechanisms by which the ERK1 and ERK2 mitogen-activated protein kinases support mutant KRAS-driven cancer growth, we determined the ERK-dependent phosphoproteome in KRAS-mutant pancreatic cancer. We determined that...
10.
Alektiar J, Shan M, Radyk M, Zhang L, Halbrook C, Lin L, et al.
PLoS One
. 2024 Jun;
19(6):e0303577.
PMID: 38843233
Malic Enzyme 1 (ME1) plays an integral role in fatty acid synthesis and cellular energetics through its production of NADPH and pyruvate. As such, it has been identified as a...