Edouard Mullarky
Overview
Explore the profile of Edouard Mullarky including associated specialties, affiliations and a list of published articles.
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17
Citations
3066
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Recent Articles
1.
Gomes A, Ilter D, Low V, Drapela S, Schild T, Mullarky E, et al.
Nat Metab
. 2022 Apr;
4(4):435-443.
PMID: 35361954
The alteration of metabolic pathways is a critical strategy for cancer cells to attain the traits necessary for metastasis in disease progression. Here, we find that dysregulation of propionate metabolism...
2.
Jeong S, Savino A, Chirayil R, Barin E, Cheng Y, Park S, et al.
Cell Metab
. 2020 Dec;
33(1):145-159.e6.
PMID: 33357456
A significant increase in dietary fructose consumption has been implicated as a potential driver of cancer. Metabolic adaptation of cancer cells to utilize fructose confers advantages for their malignant growth,...
3.
Gomes A, Ilter D, Low V, Endress J, Fernandez-Garcia J, Rosenzweig A, et al.
Nature
. 2020 Aug;
585(7824):283-287.
PMID: 32814897
The risk of cancer and associated mortality increases substantially in humans from the age of 65 years onwards. Nonetheless, our understanding of the complex relationship between age and cancer is...
4.
Gomes A, Ilter D, Low V, Rosenzweig A, Shen Z, Schild T, et al.
Cancer Cell
. 2019 Oct;
36(4):402-417.e13.
PMID: 31564638
Metastasis is the leading cause of cancer mortality. Chromatin remodeling provides the foundation for the cellular reprogramming necessary to drive metastasis. However, little is known about the nature of this...
5.
Mullarky E, Xu J, Robin A, Huggins D, Jennings A, Noguchi N, et al.
Bioorg Med Chem Lett
. 2019 Jul;
29(17):2503-2510.
PMID: 31327531
Cancer cells reprogram their metabolism to support growth and to mitigate cellular stressors. The serine synthesis pathway has been identified as a metabolic pathway frequently altered in cancers and there...
6.
Holt M, Assar Z, Zavareh R, Lin L, Anglin J, Mashadova O, et al.
Biochemistry
. 2018 Oct;
57(47):6604-6614.
PMID: 30365304
Pancreatic cancer cells are characterized by deregulated metabolic programs that facilitate growth and resistance to oxidative stress. Among these programs, pancreatic cancers preferentially utilize a metabolic pathway through the enzyme...
7.
Anglin J, Zavareh R, Sander P, Haldar D, Mullarky E, Cantley L, et al.
Bioorg Med Chem Lett
. 2018 May;
28(16):2675-2678.
PMID: 29731362
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that is extremely refractory to the therapeutic approaches that have been evaluated to date. Recently, it has been demonstrated that PDAC tumors...
8.
Ravez S, Corbet C, Spillier Q, Dutu A, Robin A, Mullarky E, et al.
J Med Chem
. 2017 Jan;
60(4):1591-1597.
PMID: 28085281
Given the putative role of PHGDH in cancer, development of inhibitors is required to explore its function. In this context, we established and validated a straightforward enzymatic assay suitable for...
9.
Mullarky E, Lairson L, Cantley L, Lyssiotis C
Mol Cell Oncol
. 2016 Sep;
3(4):e1164280.
PMID: 27652319
Serine metabolism is likely to play a critical role in cancer cell growth. A recent study reports the identification of a novel small-molecule inhibitor of serine synthesis that targets 3-phosphoglycerate...
10.
DeNicola G, Chen P, Mullarky E, Sudderth J, Hu Z, Wu D, et al.
Nat Genet
. 2016 Mar;
48(4):473.
PMID: 27023779
No abstract available.