Brian P Fiske
Overview
Explore the profile of Brian P Fiske including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
2062
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0
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Recent Articles
1.
Gera N, Fitzgerald K, Ramesh V, Patel P, Kanojia D, Colombo F, et al.
Mol Cancer Ther
. 2024 Jun;
:OF1-OF12.
PMID: 38853438
Advances in linker payload technology and target selection have been at the forefront of recent improvements in antibody-drug conjugate (ADC) design, leading to several approvals over the last decade. In...
2.
Gera N, Fitzgerald K, Ramesh V, Patel P, Kanojia D, Colombo F, et al.
Mol Cancer Ther
. 2024 Apr;
PMID: 38684230
Advances in linker payload technology and target selection have been at the forefront of recent improvements in antibody-drug conjugate (ADC) design, leading to several approvals over the last decade. In...
3.
Diehl F, Lewis C, Fiske B, Vander Heiden M
Nat Metab
. 2019 Oct;
1(9):861-867.
PMID: 31598584
The serine synthesis pathway is upregulated in many cancers. However, even cancer cells with increased serine synthesis take up large amounts of serine from the environment1 and we confirm that...
4.
Mattaini K, Sullivan M, Lau A, Fiske B, Bronson R, Vander Heiden M
BMC Cancer
. 2019 Jul;
19(1):723.
PMID: 31331318
Background: Copy number gain of the D-3-phosphoglycerate dehydrogenase (PHGDH) gene, which encodes the first enzyme in serine biosynthesis, is found in some human cancers including a subset of melanomas. Methods:...
5.
Pacold M, Brimacombe K, Chan S, Rohde J, Lewis C, Swier L, et al.
Nat Chem Biol
. 2016 Jul;
12(8):656.
PMID: 27434767
No abstract available.
6.
Pacold M, Brimacombe K, Chan S, Rohde J, Lewis C, Swier L, et al.
Nat Chem Biol
. 2016 Apr;
12(6):452-8.
PMID: 27110680
Serine is both a proteinogenic amino acid and the source of one-carbon units essential for de novo purine and deoxythymidine synthesis. In the canonical pathway of glucose-derived serine synthesis, Homo...
7.
Hosios A, Fiske B, Gui D, Vander Heiden M
Mol Cell
. 2015 Aug;
59(5):850-7.
PMID: 26300261
The role of pyruvate kinase M2 (PKM2) in cell proliferation is controversial. A unique function of PKM2 proposed to be important for the proliferation of some cancer cells involves the...
8.
Mattaini K, Brignole E, Kini M, Davidson S, Fiske B, Drennan C, et al.
Cancer Metab
. 2015 May;
3:5.
PMID: 25926973
Background: The gene encoding the serine biosynthesis pathway enzyme PHGDH is located in a region of focal genomic copy number gain in human cancers. Cells with PHGDH amplification are dependent...
9.
Kim D, Fiske B, Birsoy K, Freinkman E, Kami K, Possemato R, et al.
Nature
. 2015 Apr;
520(7547):363-7.
PMID: 25855294
Cancer cells adapt their metabolic processes to support rapid proliferation, but less is known about how cancer cells alter metabolism to promote cell survival in a poorly vascularized tumour microenvironment....
10.
Mayers J, Wu C, Clish C, Kraft P, Torrence M, Fiske B, et al.
Nat Med
. 2014 Sep;
20(10):1193-1198.
PMID: 25261994
Most patients with pancreatic ductal adenocarcinoma (PDAC) are diagnosed with advanced disease and survive less than 12 months. PDAC has been linked with obesity and glucose intolerance, but whether changes...