Karl Fisher
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Explore the profile of Karl Fisher including associated specialties, affiliations and a list of published articles.
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63
Citations
762
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Recent Articles
11.
Halliwell T, Fisher K, Payne K, Rigby S, Leys D
Microorganisms
. 2020 Sep;
8(9).
PMID: 32887524
Reductive dehalogenases are responsible for the reductive cleavage of carbon-halogen bonds during organohalide respiration. A variety of mechanisms have been proposed for these cobalamin and [4Fe-4S] containing enzymes, including organocobalt,...
12.
Halliwell T, Fisher K, Payne K, Rigby S, Leys D
Protein Expr Purif
. 2020 Sep;
177:105743.
PMID: 32871253
The family of cobalamin class-III dependent enzymes is composed of the reductive dehalogenases (RDases) and related epoxyqueuosine reductases. RDases are crucial for the energy conserving process of organohalide respiration. These...
13.
Balaikaite A, Chisanga M, Fisher K, Heyes D, Spiess R, Leys D
ACS Chem Biol
. 2020 Aug;
15(9):2466-2475.
PMID: 32840348
Prenylated flavin mononucleotide (prFMN) is a recently discovered modified flavin cofactor containing an additional nonaromatic ring, connected to the N5 and C6 atoms. This cofactor underpins reversible decarboxylation catalyzed by...
14.
Ortmayer M, Fisher K, Basran J, Wolde-Michael E, Heyes D, Levy C, et al.
ACS Catal
. 2020 Jun;
10(4):2735-2746.
PMID: 32550044
Nature employs a limited number of genetically encoded axial ligands to control diverse heme enzyme activities. Deciphering the functional significance of these ligands requires a quantitative understanding of how their...
15.
Hedison T, Shenoy R, Iorgu A, Heyes D, Fisher K, Wright G, et al.
ACS Catal
. 2020 Feb;
9(7):6087-6099.
PMID: 32051772
It is generally assumed that tethering enhances rates of electron harvesting and delivery to active sites in multidomain enzymes by proximity and sampling mechanisms. Here, we explore this idea in...
16.
Bailey S, Payne K, Saaret A, Marshall S, Gostimskaya I, Kosov I, et al.
Nat Chem
. 2019 Sep;
11(11):1049-1057.
PMID: 31527849
The UbiD enzyme plays an important role in bacterial ubiquinone (coenzyme Q) biosynthesis. It belongs to a family of reversible decarboxylases that interconvert propenoic or aromatic acids with the corresponding...
17.
Austerberry J, Thistlethwaite A, Fisher K, Golovanov A, Pluen A, Esfandiary R, et al.
Biochemistry
. 2019 Jul;
58(32):3413-3421.
PMID: 31314511
Increased protein solubility is known to correlate with an increase in the proportion of lysine over arginine residues. Previous work has shown that the aggregation propensity of a single-chain variable...
18.
Marshall S, Payne K, Fisher K, White M, Ni Cheallaigh A, Balaikaite A, et al.
Nat Commun
. 2019 May;
10(1):2357.
PMID: 31142738
The UbiX-UbiD enzymes are widespread in microbes, acting in concert to decarboxylate alpha-beta unsaturated carboxylic acids using a highly modified flavin cofactor, prenylated FMN (prFMN). UbiX serves as the flavin...
19.
Marshall S, Payne K, Fisher K, Gahloth D, Bailey S, Balaikaite A, et al.
Methods Enzymol
. 2019 May;
620:489-508.
PMID: 31072499
The recent discovery of the prenylated FMN (prFMN) cofactor has led to a renewed interest in the prFMN-dependent UbiD family of enzymes. The latter catalyses the reversible decarboxylation of alpha-beta...
20.
Payne K, Marshall S, Fisher K, Cliff M, Cannas D, Yan C, et al.
ACS Catal
. 2019 May;
9(4):2854-2865.
PMID: 31057985
The biological production of FDCA is of considerable value as a potential replacement for petrochemical-derived monomers such as terephthalate, used in polyethylene terephthalate (PET) plastics. HmfF belongs to an uncharacterized...