Colin Levy
Overview
Explore the profile of Colin Levy including associated specialties, affiliations and a list of published articles.
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50
Citations
1087
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Recent Articles
1.
Xu G, Torri D, Cuesta-Hoyos S, Panda D, Yates L, Zallot R, et al.
Nat Chem Biol
. 2024 Jul;
20(10):1371-1379.
PMID: 38951647
Nature has evolved biosynthetic pathways to molecules possessing reactive warheads that inspired the development of many therapeutic agents, including penicillin antibiotics. Peptides armed with electrophilic warheads have proven to be...
2.
Kalvet I, Ortmayer M, Zhao J, Crawshaw R, Ennist N, Levy C, et al.
J Am Chem Soc
. 2023 Jun;
145(26):14307-14315.
PMID: 37341421
The catalytic versatility of pentacoordinated iron is highlighted by the broad range of natural and engineered activities of heme enzymes such as cytochrome P450s, which position a porphyrin cofactor coordinating...
3.
Lovelock S, Crawshaw R, Basler S, Levy C, Baker D, Hilvert D, et al.
Nature
. 2022 Jun;
606(7912):49-58.
PMID: 35650353
The ability to design efficient enzymes from scratch would have a profound effect on chemistry, biotechnology and medicine. Rapid progress in protein engineering over the past decade makes us optimistic...
4.
Gahloth D, Fisher K, Payne K, Cliff M, Levy C, Leys D
J Biol Chem
. 2022 Feb;
298(4):101771.
PMID: 35218772
The ubiquitous UbiD family of reversible decarboxylases is implicated in a wide range of microbial processes and depends on the prenylated flavin mononucleotide cofactor for catalysis. However, only a handful...
5.
Crawshaw R, Crossley A, Johannissen L, Burke A, Hay S, Levy C, et al.
Nat Chem
. 2021 Dec;
14(3):313-320.
PMID: 34916595
The combination of computational design and directed evolution could offer a general strategy to create enzymes with new functions. So far, this approach has delivered enzymes for a handful of...
6.
Gautom T, Dheeman D, Levy C, Butterfield T, Alvarez Gonzalez G, Le Roy P, et al.
Nat Commun
. 2021 Oct;
12(1):6244.
PMID: 34716322
Biological degradation of Polyethylene terephthalate (PET) plastic and assimilation of the corresponding monomers ethylene glycol and terephthalate (TPA) into central metabolism offers an attractive route for bio-based molecular recycling and...
7.
Marshall S, Payne K, Fisher K, Titchiner G, Levy C, Hay S, et al.
Nat Commun
. 2021 Aug;
12(1):5065.
PMID: 34417452
The widespread UbiD enzyme family utilises the prFMN cofactor to achieve reversible decarboxylation of acrylic and (hetero)aromatic compounds. The reaction with acrylic compounds based on reversible 1,3-dipolar cycloaddition between substrate...
8.
Ortmayer M, Hardy F, Quesne M, Fisher K, Levy C, Heyes D, et al.
JACS Au
. 2021 Aug;
1(7):913-918.
PMID: 34337604
Nature employs high-energy metal-oxo intermediates embedded within enzyme active sites to perform challenging oxidative transformations with remarkable selectivity. Understanding how different local metal-oxo coordination environments control intermediate reactivity and catalytic...
9.
Winn M, Rowlinson M, Wang F, Bering L, Francis D, Levy C, et al.
Nature
. 2021 May;
593(7859):391-398.
PMID: 34012085
Coronatine and related bacterial phytotoxins are mimics of the hormone jasmonyl-L-isoleucine (JA-Ile), which mediates physiologically important plant signalling pathways. Coronatine-like phytotoxins disrupt these essential pathways and have potential in the...
10.
White M, Dalle Carbonare L, Lavilla Puerta M, Iacopino S, Edwards M, Dunne K, et al.
Proc Natl Acad Sci U S A
. 2020 Sep;
117(37):23140-23147.
PMID: 32868422
In higher plants, molecular responses to exogenous hypoxia are driven by group VII ethylene response factors (ERF-VIIs). These transcriptional regulators accumulate in the nucleus under hypoxia to activate anaerobic genes...