Jurgen Einsiedel
Overview
Explore the profile of Jurgen Einsiedel including associated specialties, affiliations and a list of published articles.
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34
Citations
252
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Recent Articles
1.
Bolik K, Hellmann J, Maschauer S, Neu E, Einsiedel J, Riss P, et al.
EJNMMI Res
. 2024 Sep;
14(1):80.
PMID: 39231867
Background: The orexin receptor (OXR) plays a role in drug addiction and is aberrantly expressed in colorectal tumors. Subtype-selective OXR PET ligands suitable for in vivo use have not yet...
2.
Distler K, Maschauer S, Neu E, Hubner H, Einsiedel J, Prante O, et al.
Bioorg Med Chem
. 2024 Jul;
110:117823.
PMID: 38964170
Molecular imaging using positron emission tomography (PET) can serve as a promising tool for visualizing biological targets in the brain. Insights into the expression pattern and the in vivo imaging...
3.
Liu F, Kaplan A, Levring J, Einsiedel J, Tiedt S, Distler K, et al.
Cell
. 2024 May;
187(14):3712-3725.e34.
PMID: 38810646
The cystic fibrosis transmembrane conductance regulator (CFTR) is a crucial ion channel whose loss of function leads to cystic fibrosis, whereas its hyperactivation leads to secretory diarrhea. Small molecules that...
4.
Sure F, Einsiedel J, Gmeiner P, Duchstein P, Zahn D, Korbmacher C, et al.
J Biol Chem
. 2024 Feb;
300(4):105785.
PMID: 38401845
The epithelial sodium channel (ENaC) is essential for mediating sodium absorption in several epithelia. Its impaired function leads to severe disorders, including pseudohypoaldosteronism type 1 and respiratory distress. Therefore, pharmacological...
5.
Liu F, Kaplan A, Levring J, Einsiedel J, Tiedt S, Distler K, et al.
bioRxiv
. 2023 Sep;
PMID: 37745391
The cystic fibrosis transmembrane conductance regulator (CFTR) is a crucial ion channel whose loss of function leads to cystic fibrosis, while its hyperactivation leads to secretory diarrhea. Small molecules that...
6.
Einsiedel J, Schmidt M, Hubner H, Gmeiner P
Bioorg Med Chem
. 2022 Mar;
61:116720.
PMID: 35334449
A broadly applicable synthesis of peptides incorporating mixed disulfides between cysteine and homocysteine and cysteamine was developed. The method was established using pharmacologically relevant G protein-coupled receptor (GPCR) ligands including...
7.
Bathe-Peters M, Gmach P, Boltz H, Einsiedel J, Gotthardt M, Hubner H, et al.
Proc Natl Acad Sci U S A
. 2021 Jun;
118(23).
PMID: 34088840
A key question in receptor signaling is how specificity is realized, particularly when different receptors trigger the same biochemical pathway(s). A notable case is the two β-adrenergic receptor (β-AR) subtypes,...
8.
Voyer D, Einsiedel J, Gmeiner P, Levesque D, Rompre P
Addict Biol
. 2021 Jan;
26(5):e13008.
PMID: 33491227
Neurotensin is an endogenous neuropeptide that acts as a potent modulator of ventral tegmental area (VTA) neurotransmission. The present study was aimed at determining VTA cell population and neurotensin receptor...
9.
Kling R, Burchardt C, Einsiedel J, Hubner H, Gmeiner P
J Mol Model
. 2019 Jun;
25(7):193.
PMID: 31209646
Crystal structures of neurotensin receptor subtype 1 (NTS1) allowed us to visualize the binding mode of the endogenous peptide hormone neurotensin and its pharmacologically active C-terminal fragment NT(8-13) within the...
10.
Maschauer S, Einsiedel J, Reich D, Hubner H, Gmeiner P, Wester H, et al.
Pharmaceuticals (Basel)
. 2017 Mar;
10(1).
PMID: 28287433
Neurotensin receptor 1 (NTS1) is overexpressed on a variety of cancer entities; for example, prostate cancer, ductal pancreatic adenocarcinoma, and breast cancer. Therefore, it represents an interesting target for the...