Harald Hubner
Overview
Explore the profile of Harald Hubner including associated specialties, affiliations and a list of published articles.
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Articles
159
Citations
2236
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Recent Articles
1.
Peri L, Matzov D, Huxley D, Rainish A, Fierro F, Sapir L, et al.
Nat Commun
. 2024 Nov;
15(1):9991.
PMID: 39557861
Bitter taste receptors (TAS2Rs), a subfamily of G-protein coupled receptors (GPCRs) expressed orally and extraorally, elicit signaling in response to a large set of tastants. Among 25 functional TAS2Rs encoded...
2.
Ertl F, Kopanchuk S, Dijon N, Veiksina S, Tahk M, Laasfeld T, et al.
J Med Chem
. 2024 Sep;
67(18):16664-16691.
PMID: 39261089
The determination of ligand-receptor binding affinities plays a key role in the development process of pharmaceuticals. While the classical radiochemical binding assay uses radioligands, fluorescence-based binding assays require fluorescent probes....
3.
Bolik K, Hellmann J, Maschauer S, Neu E, Einsiedel J, Riss P, et al.
EJNMMI Res
. 2024 Sep;
14(1):80.
PMID: 39231867
Background: The orexin receptor (OXR) plays a role in drug addiction and is aberrantly expressed in colorectal tumors. Subtype-selective OXR PET ligands suitable for in vivo use have not yet...
4.
Drakopoulos A, Koszegi Z, Seier K, Hubner H, Maurel D, Sounier R, et al.
J Med Chem
. 2024 Jul;
67(15):12618-12631.
PMID: 39044606
The delta opioid receptor (δOR or DOR) is a G protein-coupled receptor (GPCR) showing a promising profile as a drug target for nociception and analgesia. Herein, we design and synthesize...
5.
Distler K, Maschauer S, Neu E, Hubner H, Einsiedel J, Prante O, et al.
Bioorg Med Chem
. 2024 Jul;
110:117823.
PMID: 38964170
Molecular imaging using positron emission tomography (PET) can serve as a promising tool for visualizing biological targets in the brain. Insights into the expression pattern and the in vivo imaging...
6.
Vogt H, Shinkwin P, Huber M, Staffen N, Hubner H, Gmeiner P, et al.
ACS Pharmacol Transl Sci
. 2024 May;
7(5):1533-1545.
PMID: 38751637
The membrane protein family of G protein-coupled receptors (GPCRs) represents a major class of drug targets. Over the last years, the presence of additional intracellular binding sites besides the canonical...
7.
Casiraghi M, Wang H, Brennan P, Habrian C, Hubner H, Schmidt M, et al.
bioRxiv
. 2024 Apr;
PMID: 38586060
G protein coupled receptors (GPCRs) exhibit varying degrees of selectivity for different G protein isoforms. Despite the abundant structures of GPCR-G protein complexes, little is known about the mechanism of...
8.
Sink A, Gerwe H, Hubner H, Boivin-Jahns V, Fender J, Lorenz K, et al.
Chemistry
. 2024 Jan;
30(11):e202303506.
PMID: 38212242
β -adrenergic receptor (β -AR) agonists are used for the treatment of asthma and chronic obstructive pulmonary disease, but also play a role in other complex disorders including cancer, diabetes...
9.
Lahmy R, Hubner H, Lachmann D, Gmeiner P, Konig B
ChemMedChem
. 2023 Oct;
18(23):e202300228.
PMID: 37817331
Converting known ligands into photoswitchable derivatives offers the opportunity to modulate compound structure with light and hence, biological activity. In doing so, these probes provide unique control when evaluating G-protein-coupled...
10.
Li Y, Vogel C, Kalinichenko L, Hubner H, Weikert D, Schaefer N, et al.
Addict Biol
. 2023 Jul;
28(8):e13305.
PMID: 37500485
Alcohol consumption is a widespread behaviour that may eventually result in the development of alcohol use disorder (AUD). Alcohol, however, is rarely consumed in pure form but in fruit- or...