Nuska Tschammer
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Explore the profile of Nuska Tschammer including associated specialties, affiliations and a list of published articles.
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41
Citations
528
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Recent Articles
1.
Blech M, Melien R, Tschammer N, Presser B, Hinderberger D, Garidel P
Pharm Res
. 2021 Dec;
38(12):2065-2089.
PMID: 34904201
Purpose: Introduction of the activation energy (E) as a kinetic parameter to describe and discriminate monoclonal antibody (mAb) stability. Methods: E is derived from intrinsic fluorescence (IF) unfolding thermograms. An...
2.
Bartoschik T, Gupta A, Kern B, Hitchcock A, Adams N, Tschammer N
Methods Mol Biol
. 2021 Feb;
2168:51-62.
PMID: 33582986
The combination of MicroScale Thermophoresis (MST) and near-native site-specific His-tag labeling enables simple, robust, and reliable determination of the binding affinity between proteins and ligands. To demonstrate its applicability for...
3.
Wagner S, de Moura Gatti F, Silva D, Ortiz Zacarias N, Zweemer A, Hermann S, et al.
ChemMedChem
. 2020 Nov;
16(4):640-645.
PMID: 33205603
Herein we report the design and synthesis of a series of highly selective CCR2 antagonists as F-labeled PET tracers. The derivatives were evaluated extensively for their off-target profile at 48...
4.
Indrakumar S, Zalar M, Tschammer N, Pohl C, Norgaard A, Streicher W, et al.
Eur J Pharm Biopharm
. 2020 Nov;
158:11-20.
PMID: 33137420
Development of peptide therapeutics generally involves screening of excipients that inhibit peptide-peptide interactions, hence aggregation, and improve peptide stability. We used the therapeutic peptide plectasin to develop a fast screening...
5.
Kundu N, Ma X, Brox R, Fan X, Kochel T, Reader J, et al.
Breast Cancer (Auckl)
. 2019 Oct;
13:1178223419873628.
PMID: 31619923
We are seeking to identify molecular targets that are relevant to breast cancer cells with stem-like properties. There is growing evidence that cancer stem cells (CSCs) are supported by inflammatory...
6.
Insight into structural requirements for selective and/or dual CXCR3 and CXCR4 allosteric modulators
Kolaric A, Svajger U, Tomasic T, Brox R, Frank T, Minovski N, et al.
Eur J Med Chem
. 2018 May;
154:68-90.
PMID: 29777988
Based on the previously published pyrazolopyridine-based hit compound for which negative allosteric modulation of both CXCR3 and CXCR4 receptors was disclosed, we designed, synthesized and biologically evaluated a set of...
7.
Bartoschik T, Galinec S, Kleusch C, Walkiewicz K, Breitsprecher D, Weigert S, et al.
Sci Rep
. 2018 Mar;
8(1):4977.
PMID: 29563556
MicroScale Thermophoresis (MST) is a frequently used method for the quantitative characterization of intermolecular interactions with several advantages over other technologies. One of these is its capability to determine equilibrium...
8.
Brox R, Milanos L, Saleh N, Baumeister P, Buschauer A, Hofmann D, et al.
Mol Pharmacol
. 2018 Jan;
93(4):309-322.
PMID: 29343553
Our recent explorations of allosteric modulators with improved properties resulted in the identification of two biased negative allosteric modulators, BD103 (-1-{[3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-]pyrimi-din2yl]ethyl}-4-(4-fluorobutoxy)--[(1-methylpiperidin-4-yl)methyl}]butanamide) and BD064 (5-[(-{1-[3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-]pyrimidin-2-yl]ethyl-2-[4-fluoro-3-(trifluoromethyl)phenyl]acetamido)methyl]-2-fluorophenyl}boronic acid), that exhibited probe-dependent inhibition of...
9.
Thum S, Kokornaczyk A, Seki T, De Maria M, Ortiz Zacarias N, de Vries H, et al.
Eur J Med Chem
. 2017 May;
135:401-413.
PMID: 28463783
Targeting CCR2 and CCR5 receptors is considered as promising concept for the development of novel antiinflammatory drugs. Herein, we present the development of the first probe-dependent positive allosteric modulator (PAM)...
10.
Frank T, Reichel A, Larsen O, Stilp A, Rosenkilde M, Stamminger T, et al.
Cell Commun Signal
. 2016 Dec;
14(1):31.
PMID: 27955674
Background: Some herpesviruses like human cytomegalovirus (HCMV) encode viral G protein-coupled receptors that cause reprogramming of cell signaling to facilitate dissemination of the virus, prevent immune surveillance and establish life-long...