Jun-Ichi Sakamaki
Overview
Explore the profile of Jun-Ichi Sakamaki including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
1938
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0
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Recent Articles
11.
Latif A, Newcombe A, Li S, Gilroy K, Robertson N, Lei X, et al.
Nat Commun
. 2021 Jan;
12(1):241.
PMID: 33431824
Acute myeloid leukemia (AML) is a typically lethal molecularly heterogeneous disease, with few broad-spectrum therapeutic targets. Unusually, most AML retain wild-type TP53, encoding the pro-apoptotic tumor suppressor p53. MDM2 inhibitors...
12.
New M, Van Acker T, Sakamaki J, Jiang M, Saunders R, Long J, et al.
Cancer Res
. 2019 Feb;
79(8):1884-1898.
PMID: 30765601
Pancreatic ductal adenocarcinoma (PDAC) is driven by metabolic changes in pancreatic cells caused by oncogenic mutations and dysregulation of p53. PDAC cell lines and PDAC-derived xenografts grow as a result...
13.
New M, Van Acker T, Jiang M, Saunders R, Long J, Sakamaki J, et al.
Methods Mol Biol
. 2019 Jan;
1880:359-374.
PMID: 30610710
Autophagy is a highly regulated process, and its deregulation can contribute to various diseases, including cancer, immune diseases, and neurodegenerative disorders. Here we describe the design, protocol, and analysis of...
14.
Gonzalez P, OPrey J, Cardaci S, Barthet V, Sakamaki J, Beaumatin F, et al.
Nature
. 2018 Nov;
563(7733):719-723.
PMID: 30464341
It is now well established that tumours undergo changes in cellular metabolism. As this can reveal tumour cell vulnerabilities and because many tumours exhibit enhanced glucose uptake, we have been...
15.
Sakamaki J, Long J, New M, Van Acker T, Tooze S, Ryan K
Transcription
. 2017 Oct;
9(2):131-136.
PMID: 28980873
Autophagy is an essential cellular process that degrades cytoplasmic organelles and components. Precise control of autophagic activity is achieved by context-dependent signaling pathways. Recent studies have highlighted the involvement of...
16.
Sakamaki J, Ryan K
Autophagy
. 2017 Sep;
13(11):2006-2007.
PMID: 28933601
Macroautophagy/autophagy is an intracellular recycling system that delivers cytoplasmic organelles and materials to lysosomes for degradation. This process is operated by autophagy-related (ATG) genes and tightly controlled by stress-responsive signaling...
17.
Sakamaki J, Wilkinson S, Hahn M, Tasdemir N, OPrey J, Clark W, et al.
Mol Cell
. 2017 May;
66(4):517-532.e9.
PMID: 28525743
Autophagy is a membrane-trafficking process that directs degradation of cytoplasmic material in lysosomes. The process promotes cellular fidelity, and while the core machinery of autophagy is known, the mechanisms that...
18.
New M, Van Acker T, Long J, Sakamaki J, Ryan K, Tooze S
Front Oncol
. 2017 Mar;
7:28.
PMID: 28316954
Pancreatic ductal adenocarcinoma (PDAC) is one of the few cancer types where the 5-year survival rate shows no improvement. Despite conflicting evidence, the majority of data points to an essential...
19.
Daitoku H, Kaneko Y, Yoshimochi K, Matsumoto K, Araoi S, Sakamaki J, et al.
Mol Cell Biol
. 2016 Aug;
36(21):2755-2766.
PMID: 27550812
Forkhead box O (FOXO; DAF-16 in nematode) transcription factors activate a program of genes that control stress resistance, metabolism, and lifespan. Given the adverse impact of the stochastic DNA damage...
20.
Sakamaki J, Ryan K
Dev Cell
. 2016 May;
37(4):291-293.
PMID: 27219055
Macroautophagy facilitates degradation of cellular constituents and can positively or negatively affect cell death depending on the context. In this issue of Developmental Cell, Goodall and colleagues (2016) add to...