Jaclyn S Long
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Explore the profile of Jaclyn S Long including associated specialties, affiliations and a list of published articles.
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27
Citations
806
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Recent Articles
1.
Kania E, Long J, McEwan D, Welkenhuyzen K, La Rovere R, Luyten T, et al.
Cell Death Dis
. 2023 Jul;
14(7):436.
PMID: 37454104
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic cause of Parkinson's disease (PD), with growing importance also for Crohn's disease and cancer. LRRK2 is...
2.
Long J, Kania E, McEwan D, Barthet V, Brucoli M, Ladds M, et al.
Proc Natl Acad Sci U S A
. 2022 Jul;
119(28):e2113465119.
PMID: 35867735
The role of autophagy in cancer is complex. Both tumor-promoting and tumor-suppressive effects are reported, with tumor type, stage and specific genetic lesions dictating the role. This calls for analysis...
3.
Baudot A, Wang V, Leach J, OPrey J, Long J, Paulus-Hock V, et al.
Proc Natl Acad Sci U S A
. 2022 Jun;
119(26):e2111506119.
PMID: 35737835
Macroautophagy promotes cellular homeostasis by delivering cytoplasmic constituents to lysosomes for degradation [Mizushima, 20, 521-527 (2018)]. However, while most studies have focused on the mechanisms of protein degradation during this...
4.
Barthet V, Mrschtik M, Kania E, McEwan D, Croft D, OPrey J, et al.
FEBS J
. 2022 Jan;
289(13):3752-3769.
PMID: 35060334
Macroautophagy is a membrane-trafficking process that delivers cytoplasmic material to lysosomes for degradation. The process preserves cellular integrity by removing damaged cellular constituents and can promote cell survival by providing...
5.
Barthet V, Brucoli M, Ladds M, Nossing C, Kiourtis C, Baudot A, et al.
Sci Adv
. 2021 Jun;
7(23).
PMID: 34088666
Hepatocellular carcinoma (HCC) is driven by repeated rounds of inflammation, leading to fibrosis, cirrhosis, and, ultimately, cancer. A critical step in HCC formation is the transition from fibrosis to cirrhosis,...
6.
Beaumatin F, OPrey J, Barthet V, Zunino B, Parvy J, Bachmann A, et al.
Mol Cell
. 2019 Sep;
76(1):163-176.e8.
PMID: 31492633
Sensing nutrient availability is essential for appropriate cellular growth, and mTORC1 is a major regulator of this process. Mechanisms causing mTORC1 activation are, however, complex and diverse. We report here...
7.
New M, Van Acker T, Jiang M, Saunders R, Long J, Sakamaki J, et al.
Methods Mol Biol
. 2019 Jan;
1880:359-374.
PMID: 30610710
Autophagy is a highly regulated process, and its deregulation can contribute to various diseases, including cancer, immune diseases, and neurodegenerative disorders. Here we describe the design, protocol, and analysis of...
8.
Sakamaki J, Long J, New M, Van Acker T, Tooze S, Ryan K
Transcription
. 2017 Oct;
9(2):131-136.
PMID: 28980873
Autophagy is an essential cellular process that degrades cytoplasmic organelles and components. Precise control of autophagic activity is achieved by context-dependent signaling pathways. Recent studies have highlighted the involvement of...
9.
Sakamaki J, Wilkinson S, Hahn M, Tasdemir N, OPrey J, Clark W, et al.
Mol Cell
. 2017 May;
66(4):517-532.e9.
PMID: 28525743
Autophagy is a membrane-trafficking process that directs degradation of cytoplasmic material in lysosomes. The process promotes cellular fidelity, and while the core machinery of autophagy is known, the mechanisms that...
10.
New M, Van Acker T, Long J, Sakamaki J, Ryan K, Tooze S
Front Oncol
. 2017 Mar;
7:28.
PMID: 28316954
Pancreatic ductal adenocarcinoma (PDAC) is one of the few cancer types where the 5-year survival rate shows no improvement. Despite conflicting evidence, the majority of data points to an essential...