Jui-Wen Huang
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Explore the profile of Jui-Wen Huang including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
665
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Recent Articles
21.
Chen K, Tai W, Hsu C, Huang J, Liu C, Chen P, et al.
Eur J Med Chem
. 2012 Aug;
55:220-7.
PMID: 22871485
Previously, we demonstrated that the multiple kinase inhibitor sorafenib mediates the repression of phospho-STAT3 in hepatocellular carcinoma cells. In this study, we used this kinase-independent mechanism as a molecular basis...
22.
Chen K, Su J, Liu C, Huang J, Chen K, Chen W, et al.
Cancer Lett
. 2012 Apr;
321(1):27-35.
PMID: 22465052
We investigated the effects of a novel compound, SC-2001, on hepatocellular carcinoma (HCC). SC-2001, which is structurally related to the Mcl-1 inhibitor obatoclax, showed better antitumor effects than obatoclax in...
23.
Shih K, Shiau C, Chen T, Ko C, Lin C, Lin C, et al.
Bioorg Med Chem Lett
. 2011 Jul;
21(15):4490-7.
PMID: 21724393
Chemical features based 3D pharmacophore model for REarranged during Transfection (RET) tyrosine kinase were developed by using a training set of 26 structurally diverse known RET inhibitors. The best pharmacophore...
24.
Chen K, Tai W, Huang J, Hsu C, Chen W, Cheng A, et al.
Eur J Med Chem
. 2011 May;
46(7):2845-51.
PMID: 21531053
STAT3 is a transcription factor that modulates survival-directed transcription. It is persistently activated in many human cancers. Literature has shown that sorafenib, Raf kinase inhibitor, reduces Phospho-STAT3 and induces cell...
25.
Tai W, Cheng A, Shiau C, Huang H, Huang J, Chen P, et al.
J Hepatol
. 2011 Mar;
55(5):1041-8.
PMID: 21354226
Background & Aims: Recently, we reported that sorafenib sensitizes hepatocellular carcinoma (HCC) cells to TRAIL through the inhibition of signal transducer and activator of transcription 3 (STAT3). Here, we report...
26.
Monfardini I, Huang J, Beck B, Cellitti J, Pellecchia M, Domling A
J Med Chem
. 2011 Jan;
54(3):890-900.
PMID: 21241056
We report a second example of a general reaction screening approach to discover low molecular weight inhibitors of protein protein interactions. On the basis of the known pharmacophore model of...
27.
Bisson W, Zhang Z, Welsh K, Huang J, Ryan J, Reed J, et al.
Chem Biol Drug Des
. 2008 Nov;
72(5):331-6.
PMID: 19012568
The protein X-linked inhibitor of apoptosis (XIAP) plays an important role in caspase inactivation and as a consequence in the inhibition of apoptosis. It is known that IAP antagonists are...
28.
Huang J, Zhang Z, Wu B, Cellitti J, Zhang X, Dahl R, et al.
J Med Chem
. 2008 Oct;
51(22):7111-8.
PMID: 18956862
We report on a general structure- and NMR-based approach to derive druglike small molecule inhibitors of protein-protein interactions in a rapid and efficient manner. We demonstrate the utility of the...
29.
Huang J, Shiau C, Yang J, Wang D, Chiu H, Chen C, et al.
J Med Chem
. 2006 Jul;
49(15):4684-9.
PMID: 16854074
Previously, we demonstrated that the peroxisome proliferator-activated receptor gamma (PPARgamma) agonist troglitazone mediated the repression of cyclin D1 in MCF-7 breast cancer cells by facilitating proteasome-facilitated proteolysis. This PPARgamma-independent mechanism...
30.
Shiau C, Huang J, Wang D, Weng J, Yang C, Lin C, et al.
J Biol Chem
. 2006 Mar;
281(17):11819-25.
PMID: 16520381
Although the antitumor effect of alpha-tocopheryl succinate (vitamin E succinate) has been well demonstrated, its underlying mechanism remains elusive. This study provides evidence that inhibition of Bcl-xL/Bcl-2 function represents a...