Joshua H Bourne
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Explore the profile of Joshua H Bourne including associated specialties, affiliations and a list of published articles.
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12
Citations
214
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Recent Articles
1.
Suthya A, Wong C, Bourne J
Front Immunol
. 2024 May;
15:1372996.
PMID: 38817606
Tissue microenvironments during physiology and pathology are highly complex, meaning dynamic cellular activities and their interactions cannot be accurately modelled or . In particular, tissue-specific resident cells which may function...
2.
Bourne J, Perrella G, El-Awaisi J, Terry L, Tinkova V, Hogg R, et al.
J Thromb Haemost
. 2024 Apr;
22(7):2018-2026.
PMID: 38670315
Background: Free labile hemin acts as a damage-associated molecular pattern during acute and chronic hemolysis and muscle injury, supporting platelet activation and thrombosis. Objectives: To investigate the anti-thrombotic potential of...
3.
Bourne J, Campos J, Hopkin S, Whitworth K, Palis J, Senis Y, et al.
Front Immunol
. 2023 Aug;
14:1226196.
PMID: 37622117
Background: The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome has been described in both immune cells and platelets, but its role in the megakaryocyte (MK) lineage remains elusive....
4.
Krysko O, Bourne J, Kondakova E, Galova E, Whitworth K, Newby M, et al.
Front Immunol
. 2022 Oct;
13:968981.
PMID: 36225927
Background: The systemic inflammatory response post-SARS-CoV-2 infection increases pro-inflammatory cytokine production, multi-organ damage, and mortality rates. Mast cells (MC) modulate thrombo-inflammatory disease progression (, deep vein thrombosis) and the inflammatory...
5.
Colicchia M, Schrottmaier W, Perrella G, Reyat J, Begum J, Slater A, et al.
Blood
. 2022 Aug;
140(24):2626-2643.
PMID: 36026606
S100A8/A9, also known as "calprotectin" or "MRP8/14," is an alarmin primarily secreted by activated myeloid cells with antimicrobial, proinflammatory, and prothrombotic properties. Increased plasma levels of S100A8/A9 in thrombo-inflammatory diseases...
6.
Bourne J, Smith C, Jooss N, Di Y, Brown H, Montague S, et al.
Thromb Haemost
. 2022 Jul;
122(12):1988-2000.
PMID: 35817083
C-type lectin-like receptor 2 (CLEC-2) is highly expressed on platelets and a subpopulation of myeloid cells, and is critical in lymphatic development. CLEC-2 has been shown to support thrombus formation...
7.
Khan A, Reyat J, Hill H, Bourne J, Colicchia M, Newby M, et al.
Cardiovasc Res
. 2022 Jun;
118(15):3085-3096.
PMID: 35709328
Aims: Thrombotic complications and vasculopathy have been extensively associated with severe COVID-19 infection; however, the mechanisms inducing endotheliitis and the disruption of endothelial integrity in the microcirculation are poorly understood....
8.
Bourne J
Methods Mol Biol
. 2022 Jan;
2441:287-295.
PMID: 35099745
Upon injury, stable thrombi formation requires the recruitment of platelets, leukocytes, and various clotting factors, to provide sufficient inhibition of hemostasis. Classical models of thrombosis involve either ex vivo isolation...
9.
Bourne J, Beristain-Covarrubias N, Zuidscherwoude M, Campos J, Di Y, Garlick E, et al.
Front Immunol
. 2021 Jun;
12:693974.
PMID: 34163489
Platelets play a key role in the development, progression and resolution of the inflammatory response during sterile inflammation and infection, although the mechanism is not well understood. Here we show...
10.
Bourne J, Colicchia M, Di Y, Martin E, Slater A, Roumenina L, et al.
Haematologica
. 2020 May;
106(2):626-629.
PMID: 32354867
No abstract available.