Alexander Brill
Overview
Explore the profile of Alexander Brill including associated specialties, affiliations and a list of published articles.
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58
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4683
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Recent Articles
1.
Li Y, Furniss J, Vautrinot J, Williams C, Walsh T, Brill A, et al.
J Thromb Haemost
. 2024 Oct;
23(1):254-261.
PMID: 39454881
Background: Deep vein thrombosis is a major cause of morbidity and mortality globally. While its pathophysiology is complex, increasing evidence suggests a more prominent role for platelets than previously suspected....
2.
Smith C, Campos J, Brown H, Jooss N, Ivanova V, Harbi M, et al.
Blood Adv
. 2024 Jul;
8(21):5557-5570.
PMID: 38968150
Platelet C-type lectin-like receptor 2 (CLEC-2) is a hem-immunoreceptor tyrosine-based activation motif-containing receptor that has a critical role in venous thrombosis but minimal involvement in hemostasis. CLEC-2 can be blocked...
3.
Rayes J, Brill A
Blood
. 2024 May;
144(5):477-489.
PMID: 38728383
Venous thrombosis (VT) is a serious medical condition in which a blood clot forms in deep veins, often causing limb swelling and pain. Current antithrombotic therapies carry significant bleeding risks...
4.
Bourne J, Perrella G, El-Awaisi J, Terry L, Tinkova V, Hogg R, et al.
J Thromb Haemost
. 2024 Apr;
22(7):2018-2026.
PMID: 38670315
Background: Free labile hemin acts as a damage-associated molecular pattern during acute and chronic hemolysis and muscle injury, supporting platelet activation and thrombosis. Objectives: To investigate the anti-thrombotic potential of...
5.
Bourne J, Campos J, Hopkin S, Whitworth K, Palis J, Senis Y, et al.
Front Immunol
. 2023 Aug;
14:1226196.
PMID: 37622117
Background: The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome has been described in both immune cells and platelets, but its role in the megakaryocyte (MK) lineage remains elusive....
6.
Baksamawi H, Alexiadis A, Vigolo D, Brill A
Front Cardiovasc Med
. 2023 May;
10:1167884.
PMID: 37180784
Deep vein thrombosis is a life-threatening disease that takes millions of people's lives worldwide. Given both technical and ethical issues of using animals in research, it is necessary to develop...
7.
Kardeby C, Evans A, Campos J, Al-Wahaibi A, Smith C, Slater A, et al.
J Thromb Haemost
. 2023 Jan;
21(1):101-116.
PMID: 36695374
Background: Platelet endothelial aggregation receptor 1 (PEAR1) is a single-transmembrane orphan receptor primarily expressed on platelets and endothelial cells. Genetic variants of PEAR1 have repeatedly and independently been identified to...
8.
Krysko O, Bourne J, Kondakova E, Galova E, Whitworth K, Newby M, et al.
Front Immunol
. 2022 Oct;
13:968981.
PMID: 36225927
Background: The systemic inflammatory response post-SARS-CoV-2 infection increases pro-inflammatory cytokine production, multi-organ damage, and mortality rates. Mast cells (MC) modulate thrombo-inflammatory disease progression (, deep vein thrombosis) and the inflammatory...
9.
Porembskaya O, Zinserling V, Tomson V, Toropova Y, Starikova E, Maslei V, et al.
Int J Mol Sci
. 2022 May;
23(10).
PMID: 35628637
Pulmonary embolism is a life-threatening condition, which can result in respiratory insufficiency and death. Blood clots occluding branches of the pulmonary artery (PA) are traditionally considered to originate from thrombi...
10.
Bourne J, Beristain-Covarrubias N, Zuidscherwoude M, Campos J, Di Y, Garlick E, et al.
Front Immunol
. 2021 Jun;
12:693974.
PMID: 34163489
Platelets play a key role in the development, progression and resolution of the inflammatory response during sterile inflammation and infection, although the mechanism is not well understood. Here we show...