Gina Perrella
Overview
Explore the profile of Gina Perrella including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
174
Followers
0
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Recent Articles
1.
Bourne J, Perrella G, El-Awaisi J, Terry L, Tinkova V, Hogg R, et al.
J Thromb Haemost
. 2024 Apr;
22(7):2018-2026.
PMID: 38670315
Background: Free labile hemin acts as a damage-associated molecular pattern during acute and chronic hemolysis and muscle injury, supporting platelet activation and thrombosis. Objectives: To investigate the anti-thrombotic potential of...
2.
Dimitrov J, Roumenina L, Perrella G, Rayes J
Arterioscler Thromb Vasc Biol
. 2023 Jun;
43(8):1349-1361.
PMID: 37317847
Independent of etiology, hemolytic diseases are associated with thrombosis, inflammation and immune dysregulation, all together contributing to organ damage and poor outcome. Beyond anemia and the loss of the anti-inflammatory...
3.
Colicchia M, Perrella G, Gant P, Rayes J
Res Pract Thromb Haemost
. 2023 Apr;
7(2):100116.
PMID: 37063765
A state-of-the-art lecture titled "novel mechanisms of thrombo-inflammation during infection" was presented at the ISTH Congress in 2022. Platelet, neutrophil, and endothelial cell activation coordinate the development, progression, and resolution...
4.
Khan A, Rodriguez-Romera A, Reyat J, Olijnik A, Colombo M, Wang G, et al.
Cancer Discov
. 2022 Nov;
13(2):364-385.
PMID: 36351055
Significance: We present a human bone marrow organoid that supports the growth of primary cells from patients with myeloid and lymphoid blood cancers. This model allows for mechanistic studies of...
5.
Colicchia M, Schrottmaier W, Perrella G, Reyat J, Begum J, Slater A, et al.
Blood
. 2022 Aug;
140(24):2626-2643.
PMID: 36026606
S100A8/A9, also known as "calprotectin" or "MRP8/14," is an alarmin primarily secreted by activated myeloid cells with antimicrobial, proinflammatory, and prothrombotic properties. Increased plasma levels of S100A8/A9 in thrombo-inflammatory diseases...
6.
Brouns S, Tullemans B, Bulato C, Perrella G, Campello E, Spiezia L, et al.
Res Pract Thromb Haemost
. 2022 Mar;
6(2):e12678.
PMID: 35284776
Background: Low plasma levels of protein C or protein S are associated with venous thromboembolism rather than myocardial infarction. The high coagulant activity in patients with thrombophilia with a (familial)...
7.
Perrella G, Montague S, Brown H, Garcia Quintanilla L, Slater A, Stegner D, et al.
Int J Mol Sci
. 2022 Jan;
23(1).
PMID: 35008919
Understanding the pathways involved in the formation and stability of the core and shell regions of a platelet-rich arterial thrombus may result in new ways to treat arterial thrombosis. The...
8.
Perrella G, Nagy M, Watson S, Heemskerk J
Arterioscler Thromb Vasc Biol
. 2021 Sep;
41(11):2681-2692.
PMID: 34496636
The immunoglobulin receptor GPVI (glycoprotein VI) is selectively expressed on megakaryocytes and platelets and is currently recognized as a receptor for not only collagen but also a variety of plasma...
9.
Montague S, Patel P, Martin E, Slater A, Garcia Quintanilla L, Perrella G, et al.
Platelets
. 2021 Jul;
32(8):1018-1030.
PMID: 34266346
Charge interactions play a critical role in the activation of the innate immune system by damage- and pathogen-associated molecular pattern receptors. The ability of these receptors to recognize a wide...
10.
Perrella G, Huang J, Provenzale I, Swieringa F, Heubel-Moenen F, Farndale R, et al.
Arterioscler Thromb Vasc Biol
. 2020 Dec;
41(2):e97-e111.
PMID: 33267658
Objective: Fibrin is considered to strengthen thrombus formation via integrin αIIbβ3, but recent findings indicate that fibrin can also act as ligand for platelet glycoprotein VI. Approach and Results: To...