Abdullah O Khan
Overview
Explore the profile of Abdullah O Khan including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
378
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0
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Recent Articles
1.
Li R, Colombo M, Wang G, Rodriguez-Romera A, Benlabiod C, Jooss N, et al.
Sci Transl Med
. 2024 Oct;
16(768):eadj7552.
PMID: 39383242
Myeloproliferative neoplasms are stem cell-driven cancers associated with a large burden of morbidity and mortality. Most patients present with early-stage disease, but a substantial proportion progress to myelofibrosis or secondary...
2.
Barrachina M, Pernes G, Becker I, Allaeys I, Hirsch T, Groeneveld D, et al.
Nat Cardiovasc Res
. 2024 Aug;
2(8):746-763.
PMID: 39195958
Lipids contribute to hematopoiesis and membrane properties and dynamics; however, little is known about the role of lipids in megakaryopoiesis. Here we show that megakaryocyte progenitors, megakaryocytes and platelets present...
3.
Reyat J, Sommerfeld L, OReilly M, Cardoso V, Thiemann E, Khan A, et al.
Cardiovasc Res
. 2024 Aug;
120(15):1907-1923.
PMID: 39129206
Aims: Reduced left atrial PITX2 is associated with atrial cardiomyopathy and atrial fibrillation (AF). PITX2 is restricted to left atrial cardiomyocytes (aCMs) in the adult heart. The links between PITX2...
4.
Olijnik A, Rodriguez-Romera A, Wong Z, Shen Y, Reyat J, Jooss N, et al.
Nat Protoc
. 2024 Mar;
19(7):2117-2146.
PMID: 38532070
The bone marrow supports and regulates hematopoiesis, responding to physiological requirements for blood cell production over ontogeny and during pathological challenges. Interactions between hematopoietic cells and niche components are challenging...
5.
Asquith N, Carminita E, Camacho V, Rodriguez-Romera A, Stegner D, Freire D, et al.
Blood
. 2023 Oct;
143(3):272-278.
PMID: 37879046
Megakaryocytes (MKs) generate thousands of platelets over their lifespan. The roles of platelets in infection and inflammation has guided an interest to the study of extramedullary thrombopoiesis and therefore MKs...
6.
Reyat J, di Maio A, Grygielska B, Pike J, Kemble S, Rodriguez-Romero A, et al.
Front Cardiovasc Med
. 2023 Sep;
10:1156759.
PMID: 37727305
Introduction: Recent advances in human cardiac 3D approaches have yielded progressively more complex and physiologically relevant culture systems. However, their application in the study of complex pathological processes, such as...
7.
Barrachina M, Pernes G, Becker I, Allaeys I, Hirsch T, Groeneveld D, et al.
bioRxiv
. 2023 Feb;
PMID: 36798332
Lipids contribute to hematopoiesis and membrane properties and dynamics, however, little is known about the role of lipids in megakaryopoiesis. Here, a lipidomic analysis of megakaryocyte progenitors, megakaryocytes, and platelets...
8.
Khan A, Rodriguez-Romera A, Reyat J, Olijnik A, Colombo M, Wang G, et al.
Cancer Discov
. 2022 Nov;
13(2):364-385.
PMID: 36351055
Significance: We present a human bone marrow organoid that supports the growth of primary cells from patients with myeloid and lymphoid blood cancers. This model allows for mechanistic studies of...
9.
Krysko O, Bourne J, Kondakova E, Galova E, Whitworth K, Newby M, et al.
Front Immunol
. 2022 Oct;
13:968981.
PMID: 36225927
Background: The systemic inflammatory response post-SARS-CoV-2 infection increases pro-inflammatory cytokine production, multi-organ damage, and mortality rates. Mast cells (MC) modulate thrombo-inflammatory disease progression (, deep vein thrombosis) and the inflammatory...
10.
Colicchia M, Schrottmaier W, Perrella G, Reyat J, Begum J, Slater A, et al.
Blood
. 2022 Aug;
140(24):2626-2643.
PMID: 36026606
S100A8/A9, also known as "calprotectin" or "MRP8/14," is an alarmin primarily secreted by activated myeloid cells with antimicrobial, proinflammatory, and prothrombotic properties. Increased plasma levels of S100A8/A9 in thrombo-inflammatory diseases...