Josh Zaifman
Overview
Explore the profile of Josh Zaifman including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
203
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Recent Articles
1.
Jakubek Z, Chen S, Zaifman J, Tam Y, Zou S
Langmuir
. 2023 Feb;
39(7):2509-2519.
PMID: 36748988
With recent advances and anticipated proliferation of lipid nanoparticle (LNP)-delivered vaccines and therapeutics, there is a need for the availability of internationally recognized reference materials of LNP systems. Accordingly, we...
2.
Alhussan A, Jackson N, Eaton S, Dos Santos N, Barta I, Zaifman J, et al.
Cancers (Basel)
. 2022 Dec;
14(24).
PMID: 36551622
Current chemoradiation therapy suffers from normal tissue toxicity. Thus, we are proposing incorporating gold nanoparticles (GNPs) and docetaxel (DTX), as they have shown very promising synergetic radiosensitization effects. Here, we...
3.
Syama K, Jakubek Z, Chen S, Zaifman J, Tam Y, Zou S
Sci Rep
. 2022 Oct;
12(1):18071.
PMID: 36302886
Lipid based nanocarriers are one of the most effective drug delivery systems that is evident from the recent COVID-19 mRNA vaccines. The main objective of this study was to evaluate...
4.
van der Meel R, Chen S, Zaifman J, Kulkarni J, Zhang X, Tam Y, et al.
Small
. 2021 Aug;
17(37):e2103025.
PMID: 34337865
Successfully employing small interfering RNA (siRNA) therapeutics requires the use of nanotechnology for efficient intracellular delivery. Lipid nanoparticles (LNPs) have enabled the approval of various nucleic acid therapeutics. A major...
5.
Henrickson A, Kulkarni J, Zaifman J, Gorbet G, Cullis P, Demeler B
ACS Nano
. 2021 Feb;
15(3):5068-5076.
PMID: 33617224
Previous work suggested that lipid nanoparticle (LNP) formulations, encapsulating nucleic acids, display electron-dense morphology when examined by cryogenic-transmission electron microscopy (cryo-TEM). Critically, the employed cryo-TEM method cannot differentiate between loaded...
6.
Morozko E, Smith-Geater C, Monteys A, Pradhan S, Lim R, Langfelder P, et al.
Proc Natl Acad Sci U S A
. 2021 Jan;
118(4).
PMID: 33468657
DNA damage repair genes are modifiers of disease onset in Huntington's disease (HD), but how this process intersects with associated disease pathways remains unclear. Here we evaluated the mechanistic contributions...
7.
Kulkarni J, Thomson S, Zaifman J, Leung J, Wagner P, Hill A, et al.
Nanoscale
. 2020 Nov;
12(47):23959-23966.
PMID: 33241838
Lipid nanoparticle (LNP) formulations of nucleic acid are leading vaccine candidates for COVID-19, and enabled the first approved RNAi therapeutic, Onpattro. LNPs are composed of ionizable cationic lipids, phosphatidylcholine, cholesterol,...
8.
Kulkarni J, Witzigmann D, Leung J, van der Meel R, Zaifman J, Darjuan M, et al.
Nanoscale
. 2019 Apr;
11(18):9023-9031.
PMID: 31021343
The success of Onpattro™ (patisiran) clearly demonstrates the utility of lipid nanoparticle (LNP) systems for enabling gene therapies. These systems are composed of ionizable cationic lipids, phospholipid, cholesterol, and polyethylene...
9.
Chen S, Zaifman J, Kulkarni J, Zhigaltsev I, Tam Y, Ciufolini M, et al.
J Control Release
. 2018 Jul;
286:46-54.
PMID: 30026080
Lipid nanoparticles (LNPs) are playing a leading role in enabling clinical applications of gene therapies based on DNA or RNA polymers. One factor impeding clinical acceptance of LNP therapeutics is...
10.
Kulkarni J, Tam Y, Chen S, Tam Y, Zaifman J, Cullis P, et al.
Nanoscale
. 2017 Sep;
9(36):13600-13609.
PMID: 28876010
A straightforward "bottom-up" synthesis is described for efficient entrapment of inorganic hydrophobic nanoparticles (HNPs) consisting of iron oxide, gold, or quantum dots within the hydrophobic core of lipid nanoparticles (LNPs)....