Roy van der Meel
Overview
Explore the profile of Roy van der Meel including associated specialties, affiliations and a list of published articles.
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49
Citations
3119
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Recent Articles
1.
Hofstraat S, Anbergen T, Zwolsman R, Deckers J, van Elsas Y, Trines M, et al.
Nat Nanotechnol
. 2025 Feb;
PMID: 39900620
Nucleic acid therapeutics are used for silencing, expressing or editing genes in vivo. However, their systemic stability and targeted delivery to bone marrow resident cells remains a challenge. In this...
2.
Wauters A, Scheerstra J, van Leent M, Teunissen A, Priem B, Beldman T, et al.
Nat Nanotechnol
. 2024 Jul;
19(11):1735-1744.
PMID: 39085390
Regulating innate immunity is an emerging approach to improve cancer immunotherapy. Such regulation requires engaging myeloid cells by delivering immunomodulatory compounds to hematopoietic organs, including the spleen. Here we present...
3.
van der Meel R, Grisoni F, Mulder W
Nat Mater
. 2024 Jul;
23(7):880-881.
PMID: 38956348
No abstract available.
4.
Rother N, Yanginlar C, Prevot G, Jonkman I, Jacobs M, van Leent M, et al.
Cell Rep
. 2023 Nov;
42(12):113458.
PMID: 37995184
Innate immune memory, also called "trained immunity," is a functional state of myeloid cells enabling enhanced immune responses. This phenomenon is important for host defense, but also plays a role...
5.
Ziogas A, Bruno M, van der Meel R, Mulder W, Netea M
Cell Host Microbe
. 2023 Nov;
31(11):1776-1791.
PMID: 37944491
Trained immunity is a de facto memory for innate immune responses, leading to long-term functional reprogramming of innate immune cells. In physiological conditions, trained immunity leads to adaptive states that...
6.
Hofstraat S, Anbergen T, van der Meel R
Nanomedicine (Lond)
. 2023 Sep;
18(23):1607-1611.
PMID: 37724504
Tweetable abstract Commentary just out in @fsgnnm: unleashing the full potential of #cancer #nanomedicines by reprogramming the immunosuppressive #TME using #LNP #mRNA #vaccines and via promoting #trainedimmunity.
7.
Deprez J, Verbeke R, Meulewaeter S, Aernout I, Dewitte H, Decruy T, et al.
Nat Nanotechnol
. 2023 Jul;
18(11):1341-1350.
PMID: 37430039
The therapeutic potential of liposomes to deliver drugs into inflamed tissue is well documented. Liposomes are believed to largely transport drugs into inflamed joints by selective extravasation through endothelial gaps...
8.
Schrijver D, Roring R, Deckers J, de Dreu A, Toner Y, Prevot G, et al.
Nat Biomed Eng
. 2023 Jun;
7(9):1097-1112.
PMID: 37291433
Immunoparalysis is a compensatory and persistent anti-inflammatory response to trauma, sepsis or another serious insult, which increases the risk of opportunistic infections, morbidity and mortality. Here, we show that in...
9.
Deckers J, Anbergen T, Hokke A, de Dreu A, Schrijver D, de Bruin K, et al.
Nat Rev Bioeng
. 2023 Apr;
1(4):286-303.
PMID: 37064653
Cytokines have pivotal roles in immunity, making them attractive as therapeutics for a variety of immune-related disorders. However, the widespread clinical use of cytokines has been limited by their short...
10.
Quick J, Dos Santos N, Cheng M, Chander N, Brimacombe C, Kulkarni J, et al.
J Control Release
. 2022 Jul;
349:174-183.
PMID: 35780952
Advanced-stage prostate cancer remains an incurable disease with poor patient prognosis. There is an unmet clinical need to target androgen receptor (AR) splice variants, which are key drivers of the...