Joseph J Caumanns
Overview
Explore the profile of Joseph J Caumanns including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
420
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0
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Recent Articles
1.
Caumanns J, Li S, Meersma G, Duiker E, van der Zee A, Wisman G, et al.
Sci Rep
. 2025 Feb;
15(1):4434.
PMID: 39910133
Interest in understanding the high chemoresistance and poor prognosis of advanced ovarian clear cell carcinoma (OCCC) is rising. Patient-derived xenografts (PDX) are widely used in vivo models because of their...
2.
Lawson K, Sousa C, Zhang X, Kim E, Akthar R, Caumanns J, et al.
Nature
. 2020 Sep;
586(7827):120-126.
PMID: 32968282
The genetic circuits that allow cancer cells to evade destruction by the host immune system remain poorly understood. Here, to identify a phenotypically robust core set of genes and pathways...
3.
Caumanns J, van Wijngaarden A, Kol A, Meersma G, Jalving M, Bernards R, et al.
Cancer Lett
. 2019 Jul;
461:102-111.
PMID: 31319139
Advanced stage ovarian clear cell carcinoma (OCCC) is poorly responsive to platinum-based chemotherapy and has an unfavorable prognosis. Previous studies revealed heterogeneous mutations in PI3K/AKT/mTOR and MAPK pathway nodules converging...
4.
Caumanns J, Wisman G, Berns K, van der Zee A, de Jong S
Biochim Biophys Acta Rev Cancer
. 2018 Jul;
1870(2):176-184.
PMID: 30025943
SWI/SNF chromatin remodeling complexes play an important role in the epigenetic regulation of chromatin structure and gene transcription. Mutual exclusive subunits in the SWI/SNF complex include the DNA targeting members...
5.
Berns K, Caumanns J, Hijmans E, Gennissen A, Severson T, Evers B, et al.
Oncogene
. 2018 May;
37(33):4611-4625.
PMID: 29760405
Current treatment for advanced stage ovarian clear cell cancer is severely hampered by a lack of effective systemic therapy options, leading to a poor outlook for these patients. Sequencing studies...
6.
Caumanns J, Berns K, Wisman G, Fehrmann R, Tomar T, Klip H, et al.
Clin Cancer Res
. 2018 Apr;
24(16):3928-3940.
PMID: 29685880
Advanced-stage ovarian clear cell carcinoma (OCCC) is unresponsive to conventional platinum-based chemotherapy. Frequent alterations in OCCC include deleterious mutations in the tumor suppressor and activating mutations in the PI3K subunit...
7.
Geng Y, Kedrov A, Caumanns J, Crevenna A, Lamb D, Beckmann R, et al.
J Biol Chem
. 2015 May;
290(28):17250-61.
PMID: 26023232
Members of the YidC/Oxa1/Alb3 protein family mediate membrane protein insertion, and this process is initiated by the assembly of YidC·ribosome nascent chain complexes at the inner leaflet of the lipid...
8.
Kedrov A, Sustarsic M, de Keyzer J, Caumanns J, Wu Z, Driessen A
J Mol Biol
. 2013 Aug;
425(22):4112-24.
PMID: 23933010
Membrane protein biogenesis in bacteria occurs via dedicated molecular systems SecYEG and YidC that function independently and in cooperation. YidC belongs to the universally conserved Oxa1/Alb3/YidC family of membrane insertases...