Rene Bernards
Overview
Explore the profile of Rene Bernards including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
253
Citations
26606
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Ratze M, Enserink L, Ishiyama N, van Kempen S, Veltman C, Nijman I, et al.
J Pathol
. 2025 Mar;
PMID: 40026293
Afadin is a multimodal scaffolding protein with essential functions in cell-cell adhesion. Although its loss of expression has been linked to breast cancer invasion and metastasis, the underlying mechanisms driving...
2.
Zheng J, Wang S, Xia L, Sun Z, Chan K, Bernards R, et al.
Signal Transduct Target Ther
. 2025 Feb;
10(1):35.
PMID: 39915447
Liver cancer represents a major global health concern, with projections indicating that the number of new cases could surpass 1 million annually by 2025. Hepatocellular carcinoma (HCC) constitutes around 90%...
3.
Cao Y, Qian R, Yao R, Zheng Q, Yang C, Yang X, et al.
Dev Cell
. 2025 Jan;
PMID: 39798576
Intervening in mitochondrial oxidative phosphorylation (OXPHOS) has emerged as a potential therapeutic strategy for certain types of cancers. Employing kinome-based CRISPR screen, we find that knockout of dual-specificity tyrosine phosphorylation-regulated...
4.
MacDonald J, Bradshaw G, Jochems F, Bernards R, Letai A
Cell Death Differ
. 2025 Jan;
PMID: 39762561
Cellular senescence contributes to a variety of pathologies associated with aging and is implicated as a cellular state in which cancer cells can survive treatment. Reported senolytic drug treatments act...
5.
Wang J, Liao L, Miao B, Yang B, Li B, Ma X, et al.
Proc Natl Acad Sci U S A
. 2024 Dec;
122(1):e2419625121.
PMID: 39739814
Ferroptosis, a unique form of iron-dependent cell death triggered by lipid peroxidation accumulation, holds great promise for cancer therapy. Despite the crucial role of GPX4 in regulating ferroptosis, our understanding...
6.
Jochems F, Baltira C, MacDonald J, Daniels V, Mathur A, de Gooijer M, et al.
Cell Death Differ
. 2024 Dec;
PMID: 39706991
Cellular senescence is a stress response that cells can employ to resist cell death. Senescent cells rely on anti-apoptotic signaling for their survival, which can be targeted by senolytic agents,...
7.
Casagrande Raffi G, Chen J, Feng X, Chen Z, Lieftink C, Deng S, et al.
Proc Natl Acad Sci U S A
. 2024 Dec;
121(52):e2417724121.
PMID: 39693343
Drugs that eliminate senescent cells, senolytics, can be powerful when combined with prosenescence cancer therapies. Using a CRISPR/Cas9-based genetic screen, we identify here SLC25A23 as a vulnerability of senescent cancer...
8.
Jia Q, Sun X, Li H, Guo J, Niu K, Chan K, et al.
Gut
. 2024 Dec;
PMID: 39658264
Perturbation of mRNA splicing is commonly observed in human cancers and plays a role in various aspects of cancer hallmarks. Understanding the mechanisms and functions of alternative splicing (AS) not...
9.
Shi Y, Cui D, Xia L, Shi D, Jin G, Wang S, et al.
Signal Transduct Target Ther
. 2024 Dec;
9(1):359.
PMID: 39653700
Lenvatinib, a multi-kinase inhibitor, has been approved as first-line treatment for advanced hepatocellular carcinoma (HCC), but its efficacy is limited. We have shown previously that lenvatinib and epidermal growth factor...
10.
Yang C, Geng H, Yang X, Ji S, Liu Z, Feng H, et al.
Cancer Cell
. 2024 Nov;
42(12):2064-2081.e19.
PMID: 39515328
Tumor-initiating cells (TICs) possess the ability to evade anti-tumor immunity, potentially explaining many failures of cancer immunotherapy. Here, we identify CD49f as a prominent marker for discerning TICs in hepatocellular...