Joseph A Mindell
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Explore the profile of Joseph A Mindell including associated specialties, affiliations and a list of published articles.
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38
Citations
2353
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Recent Articles
1.
Li Y, Song J, Mikusevic V, Marden J, Becerril A, Kuang H, et al.
Nat Struct Mol Biol
. 2024 Dec;
PMID: 39622972
The human high-affinity sodium-dicarboxylate cotransporter (NaDC3) imports various substrates into the cell as tricarboxylate acid cycle intermediates, lipid biosynthesis precursors and signaling molecules. Understanding the cellular signaling process and developing...
2.
Schmidt S, Nygaard A, Mindell J, Loland C
Elife
. 2024 Jan;
12.
PMID: 38271216
The neurotransmitter:sodium symporters (NSSs) are secondary active transporters that couple the reuptake of substrate to the symport of one or two sodium ions. One bound Na (Na1) contributes to the...
3.
Cao X, Lenk G, Mikusevic V, Mindell J, Meisler M
PLoS Genet
. 2023 Jun;
19(6):e1010800.
PMID: 37363915
The phosphatase FIG4 and the scaffold protein VAC14 function in the biosynthesis of PI(3,5)P2, a signaling lipid that inhibits the lysosomal chloride transporter ClC-7. Loss-of-function mutations of FIG4 and VAC14...
4.
Leray X, Hilton J, Nwangwu K, Becerril A, Mikusevic V, Fitzgerald G, et al.
Elife
. 2022 Jun;
11.
PMID: 35670560
The acidic luminal pH of lysosomes, maintained within a narrow range, is essential for proper degrative function of the organelle and is generated by the action of a V-type H...
5.
Montano C, Cassini T, Ziegler S, Boehm M, Nicoli E, Mindell J, et al.
J Inherit Metab Dis
. 2022 May;
45(5):907-918.
PMID: 35490291
Living with an undiagnosed medical condition places a tremendous burden on patients, their families, and their healthcare providers. The Undiagnosed Diseases Program (UDP) was established at the National Institutes of...
6.
Sauer D, Song J, Wang B, Hilton J, Karpowich N, Mindell J, et al.
Nature
. 2021 Feb;
591(7848):157-161.
PMID: 33597751
Citrate is best known as an intermediate in the tricarboxylic acid cycle of the cell. In addition to this essential role in energy metabolism, the tricarboxylate anion also acts as...
7.
Sampson C, Stewart M, Mindell J, Mulligan C
J Biol Chem
. 2020 Oct;
295(52):18524-18538.
PMID: 33087444
The ivalent nion odium ymporter (DASS) family (SLC13) plays critical roles in metabolic homeostasis, influencing many processes, including fatty acid synthesis, insulin resistance, and adiposity. DASS transporters catalyze the Na-driven...
8.
Singh A, Marcoline F, Veshaguri S, Kao A, Bruchez M, Mindell J, et al.
PLoS Comput Biol
. 2019 Dec;
15(12):e1007539.
PMID: 31869334
The lumenal pH of an organelle is one of its defining characteristics and central to its biological function. Experiments have elucidated many of the key pH regulatory elements and how...
9.
Nicoli E, Weston M, Hackbarth M, Becerril A, Larson A, Zein W, et al.
Am J Hum Genet
. 2019 Jun;
104(6):1127-1138.
PMID: 31155284
Optimal lysosome function requires maintenance of an acidic pH maintained by proton pumps in combination with a counterion transporter such as the Cl/H exchanger, CLCN7 (ClC-7), encoded by CLCN7. The...
10.
Weston M, Mindell J
Biochem Cell Biol
. 2018 Nov;
97(3):315-324.
PMID: 30383978
Endocytic organelles maintain their acidic pH using the V-type ATPase proton pump. However, proton accumulation across the membrane generates a voltage and requires the movement of an additional ion, known...