Christopher Mulligan
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Explore the profile of Christopher Mulligan including associated specialties, affiliations and a list of published articles.
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20
Citations
387
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Recent Articles
1.
Davies J, Daab A, Massouh N, Kirkland C, Strongitharm B, Leech A, et al.
J Gen Physiol
. 2024 Nov;
156(12).
PMID: 39556531
Tripartite ATP-independent periplasmic (TRAP) transporters are widespread in prokaryotes and are responsible for the transport of a variety of different ligands, primarily organic acids. TRAP transporters can be divided into...
2.
Elston R, Mulligan C, Thomas G
Microbiology (Reading)
. 2023 Nov;
169(11).
PMID: 37948297
The controlled entry and expulsion of small molecules across the bacterial cytoplasmic membrane is essential for efficient cell growth and cellular homeostasis. While much is known about the transcriptional regulation...
3.
Halamka T, Raberg J, McFarlin J, Younkin A, Mulligan C, Liu X, et al.
Geobiology
. 2022 Sep;
21(1):102-118.
PMID: 36150122
Branched glycerol dialkyl glycerol tetraethers (brGDGTs) are bacterial membrane lipids that are frequently employed as paleoenvironmental proxies because of the strong empirical correlations between their relative abundances and environmental temperature...
4.
Sauer D, Marden J, Sudar J, Song J, Mulligan C, Wang D
Nat Commun
. 2022 May;
13(1):2644.
PMID: 35551191
The Na-dependent dicarboxylate transporter from Vibrio cholerae (VcINDY) is a prototype for the divalent anion sodium symporter (DASS) family. While the utilization of an electrochemical Na gradient to power substrate...
5.
Scarsbrook H, Urban R, Streather B, Moores A, Mulligan C
Microbiology (Reading)
. 2021 Dec;
167(12).
PMID: 34914576
Maintaining membrane integrity is of paramount importance to the survival of bacteria as the membrane is the site of multiple crucial cellular processes including energy generation, nutrient uptake and antimicrobial...
6.
Sampson C, Fabregas Bellavista C, Stewart M, Mulligan C
Biochem J
. 2021 Oct;
478(21):3847-3867.
PMID: 34643224
The divalent anion sodium symporter (DASS) family of transporters (SLC13 family in humans) are key regulators of metabolic homeostasis, disruption of which results in protection from diabetes and obesity, and...
7.
Sampson C, Stewart M, Mindell J, Mulligan C
J Biol Chem
. 2020 Oct;
295(52):18524-18538.
PMID: 33087444
The ivalent nion odium ymporter (DASS) family (SLC13) plays critical roles in metabolic homeostasis, influencing many processes, including fatty acid synthesis, insulin resistance, and adiposity. DASS transporters catalyze the Na-driven...
8.
Mulligan C, Mindell J
Methods Enzymol
. 2017 Aug;
594:165-202.
PMID: 28779840
Transporters are crucial in a number of cellular functions, including nutrient uptake, cell signaling, and toxin removal. As such, transporters are important drug targets and their malfunction is related to...
9.
Fitzgerald G, Mulligan C, Mindell J
Elife
. 2017 Jan;
6.
PMID: 28121290
The number of ions required to drive substrate transport through a secondary active transporter determines the protein's ability to create a substrate gradient, a feature essential to its physiological function,...
10.
Mulligan C, Fenollar-Ferrer C, Fitzgerald G, Vergara-Jaque A, Kaufmann D, Li Y, et al.
Nat Struct Mol Biol
. 2016 Feb;
23(3):256-63.
PMID: 26828963
Secondary transporters use alternating-access mechanisms to couple uphill substrate movement to downhill ion flux. Most known transporters use a 'rocking bundle' motion, wherein the protein moves around an immobile substrate-binding...