Joseph A Mindell
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Explore the profile of Joseph A Mindell including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
2353
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Recent Articles
11.
Shlosman I, Marinelli F, Faraldo-Gomez J, Mindell J
J Gen Physiol
. 2017 Dec;
150(1):51-65.
PMID: 29237756
Intracellular Ca signals control a wide array of cellular processes. These signals require spatial and temporal regulation of the intracellular Ca concentration, which is achieved in part by a class...
12.
Mulligan C, Mindell J
Methods Enzymol
. 2017 Aug;
594:165-202.
PMID: 28779840
Transporters are crucial in a number of cellular functions, including nutrient uptake, cell signaling, and toxin removal. As such, transporters are important drug targets and their malfunction is related to...
13.
Fitzgerald G, Mulligan C, Mindell J
Elife
. 2017 Jan;
6.
PMID: 28121290
The number of ions required to drive substrate transport through a secondary active transporter determines the protein's ability to create a substrate gradient, a feature essential to its physiological function,...
14.
Marcoline F, Ishida Y, Mindell J, Nayak S, Grabe M
Bone
. 2016 Sep;
93:167-180.
PMID: 27650914
Bone resorption by osteoclasts occurs through the creation of a sealed extracellular compartment (ECC), or pit, adjacent to the bone that is subsequently acidified through a complex biological process. The...
15.
Mulligan C, Fenollar-Ferrer C, Fitzgerald G, Vergara-Jaque A, Kaufmann D, Li Y, et al.
Nat Struct Mol Biol
. 2016 Feb;
23(3):256-63.
PMID: 26828963
Secondary transporters use alternating-access mechanisms to couple uphill substrate movement to downhill ion flux. Most known transporters use a 'rocking bundle' motion, wherein the protein moves around an immobile substrate-binding...
16.
Vergara-Jaque A, Fenollar-Ferrer C, Mulligan C, Mindell J, Forrest L
J Gen Physiol
. 2015 Oct;
146(5):423-34.
PMID: 26503722
Membrane transporter proteins catalyze the passage of a broad range of solutes across cell membranes, allowing the uptake and efflux of crucial compounds. Because of the difficulty of expressing, purifying,...
17.
Compton E, Mindell J
EcoSal Plus
. 2015 Oct;
4(1).
PMID: 26443789
Bacterial ion channels were known, but only in special cases, such as outer membrane porins in Escherichia coli and bacterial toxins that form pores in their target (bacterial or mammalian)...
18.
Lau W, Johnson C, Lioi S, Mindell J
ACM Conf Bioinform Comput Biol Biomed Inform (2013)
. 2015 Jan;
2013:722.
PMID: 25621319
Lysosomes are subcellular organelles playing a vital role in the endocytosis process of the cell. Lysosomal acidity is an important factor in assuring proper functioning of the enzymes within the...
19.
Parker J, Mindell J, Newstead S
Elife
. 2014 Dec;
3.
PMID: 25457052
Peptide transport plays an important role in cellular homeostasis as a key route for nitrogen acquisition in mammalian cells. PepT1 and PepT2, the mammalian proton coupled peptide transporters (POTs), function...
20.
Mulligan C, Fitzgerald G, Wang D, Mindell J
J Gen Physiol
. 2014 May;
143(6):745-59.
PMID: 24821967
The SLC13 transporter family, whose members play key physiological roles in the regulation of fatty acid synthesis, adiposity, insulin resistance, and other processes, catalyzes the transport of Krebs cycle intermediates...