Brian Raught
Overview
Explore the profile of Brian Raught including associated specialties, affiliations and a list of published articles.
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Articles
169
Citations
9335
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Recent Articles
1.
Zhu H, Sydor A, Yan B, Li R, Boniecki M, Lyons C, et al.
Nat Commun
. 2025 Mar;
16(1):2329.
PMID: 40057496
Salmonella utilizes type 3 secreted effector proteins to induce plasma membrane (PM) perturbations during invasion of host cells. The effectors drive mobilization of host membranes to generate cell surface ruffles,...
2.
Feng Y, Goncalves M, Jitkova Y, Keszei A, Yan Y, Sarathy C, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(5):e2422447122.
PMID: 39879245
ClpXP is a two-component mitochondrial matrix protease. The caseinolytic mitochondrial matrix peptidase chaperone subunit X (ClpX) recognizes and translocates protein substrates into the degradation chamber of the caseinolytic protease P...
3.
Ho J, Cheng E, Wong C, St-Germain J, Dunham W, Raught B, et al.
EMBO Rep
. 2025 Jan;
26(5):1290-1314.
PMID: 39870965
Homologous recombination is a largely error-free DNA repair mechanism conserved across all domains of life and is essential for the maintenance of genome integrity. Not only are the mutations in...
4.
Baker H, Bernardini J, Csizmok V, Madero A, Kamat S, Eng H, et al.
J Cell Sci
. 2024 Dec;
138(1.
PMID: 39618332
Mutations can disrupt the native function of protein by causing misfolding, which is generally handled by an intricate protein quality control network. To better understand the triaging mechanisms for misfolded...
5.
Nucleolar Pol II interactome reveals TBPL1, PAF1, and Pol I at intergenic rDNA drive rRNA biogenesis
Khosraviani N, Yerlici V, St-Germain J, Hou Y, Cao S, Ghali C, et al.
Nat Commun
. 2024 Nov;
15(1):9603.
PMID: 39505901
Ribosomal DNA (rDNA) repeats harbor ribosomal RNA (rRNA) genes and intergenic spacers (IGS). RNA polymerase (Pol) I transcribes rRNA genes yielding rRNA components of ribosomes. IGS-associated Pol II prevents Pol...
6.
Rudnik S, Heybrock S, Coyaud E, Xu Z, Neculai D, Raught B, et al.
J Cell Sci
. 2024 Oct;
137(22).
PMID: 39370902
LIMP-2 (also known as SCARB2) is an abundant lysosomal membrane protein. Previous studies have shown that LIMP-2 functions as a virus receptor, a chaperone for lysosomal enzyme targeting and a...
7.
Rondeau V, Berman J, Ling T, OBrien C, Culp-Hill R, Reisz J, et al.
Sci Transl Med
. 2024 Sep;
16(766):eadn1285.
PMID: 39321266
Acute myeloid leukemia (AML) is a devastating disease initiated and maintained by a rare subset of cells called leukemia stem cells (LSCs). LSCs are responsible for driving disease relapse, making...
8.
Walton J, Ng A, Arevalo K, Apostoli A, Meens J, Karamboulas C, et al.
Nat Commun
. 2024 Sep;
15(1):8232.
PMID: 39300069
In addition to the ubiquitous loss of the VHL gene in clear cell renal cell carcinoma (ccRCC), co-deletions of chromatin-regulating genes are common drivers of tumorigenesis, suggesting potential vulnerability to...
9.
Zheng Y, Chen J, Macwan V, Dixon C, Li X, Liu S, et al.
Nat Metab
. 2024 Aug;
6(8):1549-1565.
PMID: 39143266
Lipid droplets (LDs) are organelles specialized in the storage of neutral lipids, cholesterol esters and triglycerides, thereby protecting cells from the toxicity of excess lipids while allowing for the mobilization...
10.
Nie D, Tabor J, Li J, Kutera M, St-Germain J, Hanley R, et al.
Nat Chem Biol
. 2024 Jul;
20(12):1597-1607.
PMID: 38965384
Targeted protein degradation (TPD) is an emerging therapeutic strategy that would benefit from new chemical entities with which to recruit a wider variety of ubiquitin E3 ligases to target proteins...