Jonathan Cairns
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Explore the profile of Jonathan Cairns including associated specialties, affiliations and a list of published articles.
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25
Citations
1612
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Recent Articles
1.
Kim C, Cairns J, Quarantotti V, Kaczkowski B, Wang Y, Konings P, et al.
PLoS One
. 2024 Aug;
19(8):e0307445.
PMID: 39163294
An arrayed CRISPR screen is a high-throughput functional genomic screening method, which typically uses 384 well plates and has different gene knockouts in different wells. Despite various computational workflows, there...
2.
Rigal S, Casas B, Kanebratt K, Wennberg Huldt C, Magnusson L, Mullers E, et al.
Commun Biol
. 2024 Jul;
7(1):877.
PMID: 39025915
Current research on metabolic disorders and diabetes relies on animal models because multi-organ diseases cannot be well studied with standard in vitro assays. Here, we have connected cell models of...
3.
Jackman M, Li W, Smith A, Workman D, Treacher K, Corrigan A, et al.
J Control Release
. 2023 Nov;
365:491-506.
PMID: 38030083
Nanoparticle (NP) formulations are inherently polydisperse making their structural characterization and justification of specifications complex. It is essential, however, to gain an understanding of the physico-chemical properties that drive performance...
4.
Lawson M, Cureton N, Ros S, Cheraghchi-Bashi A, Urosevic J, DArcy S, et al.
Cancer Res
. 2023 Sep;
83(23):3989-4004.
PMID: 37725704
Significance: Camizestrant, a next-generation oral SERD, shows promise in preclinical models of ER+ breast cancer alone and in combination with CDK4/6 and PI3K/AKT/mTOR inhibitors to address endocrine resistance, a current...
5.
Cairns J, Leonard E, Khan K, Parks C, Maglennon G, Zhang B, et al.
Front Pharmacol
. 2023 Apr;
14:1142581.
PMID: 37063297
Microphysiological systems (MPS; organ-on-a-chip) aim to recapitulate the 3D organ microenvironment and improve clinical predictivity relative to previous approaches. Though MPS studies provide great promise to explore treatment options in...
6.
Freire-Pritchett P, Ray-Jones H, Della Rosa M, Eijsbouts C, Orchard W, Wingett S, et al.
Nat Protoc
. 2021 Aug;
16(9):4144-4176.
PMID: 34373652
Capture Hi-C is widely used to obtain high-resolution profiles of chromosomal interactions involving, at least on one end, regions of interest such as gene promoters. Signal detection in Capture Hi-C...
7.
Gill S, Wijnhoven P, Fok J, Lloyd R, Cairns J, Armenia J, et al.
Mol Cancer Ther
. 2021 Jun;
20(9):1614-1626.
PMID: 34158341
Radiotherapy is an effective anticancer treatment, but combinations with targeted agents that maximize efficacy while sparing normal tissue are needed. Here, we assess the radiopotentiation profiles of DNA damage response...
8.
Furlan-Magaril M, Ando-Kuri M, Arzate-Mejia R, Morf J, Cairns J, Roman-Figueroa A, et al.
Genome Biol
. 2021 Jun;
22(1):162.
PMID: 34099014
Background: Circadian gene expression is essential for organisms to adjust their physiology and anticipate daily changes in the environment. The molecular mechanisms controlling circadian gene transcription are still under investigation....
9.
Davies G, Semple H, McCandless M, Cairns J, Holdgate G
SLAS Discov
. 2021 Jan;
26(2):248-256.
PMID: 33482076
Enzymes represent a significant proportion of the druggable genome and constitute a rich source of drug targets. Delivery of a successful program for developing a modulator of enzyme activity requires...
10.
Fok J, Ramos-Montoya A, Vazquez-Chantada M, Wijnhoven P, Follia V, James N, et al.
Nat Commun
. 2019 Nov;
10(1):5065.
PMID: 31699977
DNA-dependent protein kinase (DNA-PK) is a critical player in the DNA damage response (DDR) and instrumental in the non-homologous end-joining pathway (NHEJ) used to detect and repair DNA double-strand breaks...