Mikhail Spivakov
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Explore the profile of Mikhail Spivakov including associated specialties, affiliations and a list of published articles.
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47
Citations
4541
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Recent Articles
1.
Ray-Jones H, Sung C, Chan L, Haglund A, Artemov P, Della Rosa M, et al.
Nat Commun
. 2025 Jan;
16(1):970.
PMID: 39870618
Gene enhancers often form long-range contacts with promoters, but it remains unclear if the activity of enhancers and their chromosomal contacts are mediated by the same DNA sequences and recruited...
2.
Lambert J, Oc S, Worssam M, Haussler D, Solomon C, Figg N, et al.
Nat Cardiovasc Res
. 2024 Aug;
3(6):714-733.
PMID: 39215134
Aberrant vascular smooth muscle cell (VSMC) homeostasis and proliferation characterize vascular diseases causing heart attack and stroke. Here we elucidate molecular determinants governing VSMC proliferation by reconstructing gene regulatory networks...
3.
Worssam M, Lambert J, Oc S, Taylor J, Taylor A, Dobnikar L, et al.
Cardiovasc Res
. 2022 Aug;
119(5):1279-1294.
PMID: 35994249
Aims: Quiescent, differentiated adult vascular smooth muscle cells (VSMCs) can be induced to proliferate and switch phenotype. Such plasticity underlies blood vessel homeostasis and contributes to vascular disease development. Oligoclonal...
4.
Ray-Jones H, Spivakov M
Dev Cell
. 2022 Jun;
57(12):1439-1441.
PMID: 35728521
In a recent issue of Nature, Zuin et al. (2022) integrate a transcriptional enhancer into various genomic locations surrounding a reporter gene promoter in order to determine how enhancer-promoter proximity...
5.
Thiecke M, Yang E, Burren O, Ray-Jones H, Spivakov M
Front Genet
. 2021 Nov;
12:745672.
PMID: 34759959
Genetic variants showing associations with specific biological traits and diseases detected by genome-wide association studies (GWAS) commonly map to non-coding DNA regulatory regions. Many of these regions are located considerable...
6.
Ray-Jones H, Spivakov M
Cell Mol Life Sci
. 2021 Aug;
78(19-20):6453-6485.
PMID: 34414474
Transcriptional enhancers play a key role in the initiation and maintenance of gene expression programmes, particularly in metazoa. How these elements control their target genes in the right place and...
7.
Freire-Pritchett P, Ray-Jones H, Della Rosa M, Eijsbouts C, Orchard W, Wingett S, et al.
Nat Protoc
. 2021 Aug;
16(9):4144-4176.
PMID: 34373652
Capture Hi-C is widely used to obtain high-resolution profiles of chromosomal interactions involving, at least on one end, regions of interest such as gene promoters. Signal detection in Capture Hi-C...
8.
Watt S, Vasquez L, Walter K, Mann A, Kundu K, Chen L, et al.
Nat Commun
. 2021 Apr;
12(1):2298.
PMID: 33863903
Neutrophils play fundamental roles in innate immune response, shape adaptive immunity, and are a potentially causal cell type underpinning genetic associations with immune system traits and diseases. Here, we profile...
9.
Ho J, Mok B, Campisi L, Jordan T, Yildiz S, Parameswaran S, et al.
Cell
. 2021 Apr;
184(10):2618-2632.e17.
PMID: 33836156
The ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently affecting millions of lives worldwide. Large retrospective studies indicate that an elevated level of inflammatory cytokines...
10.
Ho J, Mok B, Campisi L, Jordan T, Yildiz S, Parameswaran S, et al.
bioRxiv
. 2020 Dec;
PMID: 33299999
The ongoing pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is currently affecting millions of lives worldwide. Large retrospective studies indicate that an elevated level of inflammatory cytokines...