Chris Wallace
Overview
Explore the profile of Chris Wallace including associated specialties, affiliations and a list of published articles.
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Articles
125
Citations
13093
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Recent Articles
1.
Lin W, Kartawinata M, Jebson B, Restuadi R, Peckham H, Radziszewska A, et al.
PLoS Comput Biol
. 2025 Mar;
21(3):e1012859.
PMID: 40053530
Gene expression studies often use bulk RNA sequencing of mixed cell populations because single cell or sorted cell sequencing may be prohibitively expensive. However, mixed cell studies may miss expression...
2.
Ray-Jones H, Sung C, Chan L, Haglund A, Artemov P, Della Rosa M, et al.
Nat Commun
. 2025 Jan;
16(1):970.
PMID: 39870618
Gene enhancers often form long-range contacts with promoters, but it remains unclear if the activity of enhancers and their chromosomal contacts are mediated by the same DNA sequences and recruited...
3.
Willis T, Gkrania-Klotsas E, Wareham N, McKinney E, Lyons P, Smith K, et al.
Clin Immunol
. 2024 Sep;
268():110356.
PMID: 39241920
Selective IgA deficiency (SIgAD) is the most common inborn error of immunity (IEI). Unlike many IEIs, evidence of a role for highly penetrant rare variants in SIgAD is lacking. Previous...
4.
Nicholls K, Kirk P, Wallace C
PLoS Comput Biol
. 2024 Sep;
20(9):e1012301.
PMID: 39226325
Clustering is widely used in bioinformatics and many other fields, with applications from exploratory analysis to prediction. Many types of data have associated uncertainty or measurement error, but this is...
5.
Reales G, Amos C, Benveniste O, Chinoy H, de Bleecker J, De Paepe B, et al.
HGG Adv
. 2024 Jul;
5(4):100336.
PMID: 39044428
Genome-wide association studies (GWASs) have been successful at finding associations between genetic variants and human traits, including the immune-mediated diseases (IMDs). However, the requirement of large sample sizes for discovery...
6.
Manipur I, Reales G, Sul J, Shin M, Longerich S, Cortes A, et al.
Nat Commun
. 2024 Jul;
15(1):5862.
PMID: 38997278
Phenome-wide association studies (PheWAS) facilitate the discovery of associations between a single genetic variant with multiple phenotypes. For variants which impact a specific protein, this can help identify additional therapeutic...
7.
Casares-Marfil D, Martinez-Bueno M, Borghi M, Pons-Estel G, Reales G, Zuo Y, et al.
Arthritis Rheumatol
. 2024 Jul;
76(11):1623-1634.
PMID: 38973605
Objective: Primary antiphospholipid syndrome (PAPS) is a rare autoimmune disease characterized by the presence of antiphospholipid antibodies and the occurrence of thrombotic events and pregnancy complications. Our study aimed to...
8.
Kelemen M, Vigorito E, Fachal L, Anderson C, Wallace C
Am J Hum Genet
. 2024 May;
111(6):1006-1017.
PMID: 38703768
We present shaPRS, a method that leverages widespread pleiotropy between traits or shared genetic effects across ancestries, to improve the accuracy of polygenic scores. The method uses genome-wide summary statistics...
9.
Casares-Marfil D, Martinez-Bueno M, Borghi M, Pons-Estel G, Reales G, Zuo Y, et al.
medRxiv
. 2024 Feb;
PMID: 38405993
Objectives: Primary antiphospholipid syndrome (PAPS) is a rare autoimmune disease characterized by the presence of antiphospholipid antibodies and the occurrence of thrombotic events and pregnancy complications. Our study aimed to...
10.
Wallace C, Gordon M, Sinopoulou V, Limketkai B
Cochrane Database Syst Rev
. 2023 Oct;
10:CD011806.
PMID: 37781953
Background: Vitamin D possesses immunomodulatory properties and has been implicated in the pathogenesis and severity of inflammatory bowel disease (IBD). Animal studies and emerging epidemiological evidence have demonstrated an association...