John N Freskos
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Explore the profile of John N Freskos including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
119
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Recent Articles
1.
Lee N, Sun G, Lin L, Neumann W, Freskos J, Karwa A, et al.
J Mater Chem
. 2014 Dec;
21(37):14193-14202.
PMID: 25506129
Dual-emitting photonic nano-objects that can sense changes in the environmental pH are designed based on shell-crosslinked micelles assembled from amphiphilic block copolymers and crosslinked with pH-insensitive chromophores. The chromophoric crosslinkers...
2.
Freskos J, Asmelash B, Gaston K, Karwa A, Marzan T, Nickols M, et al.
Bioorg Med Chem Lett
. 2013 Sep;
23(20):5566-70.
PMID: 23999043
We describe the synthesis, MMP-2 and 9 potency, and in vitro evaluation of a series of α-sulfone hydroxmate MMP inhibitors conjugated to a series of dyes with different absorption/emission lamina...
3.
Remacle A, Shiryaev S, Golubkov V, Freskos J, Brown M, Karwa A, et al.
J Biol Chem
. 2013 Jun;
288(28):20568-80.
PMID: 23733191
Proteolytic activity of cell surface-associated MT1-matrix metalloproteinase (MMP) (MMP-14) is directly related to cell migration, invasion, and metastasis. MT1-MMP is regulated as a proteinase by activation and conversion of the...
4.
Poreddy A, Neumann W, Freskos J, Rajagopalan R, Asmelash B, Gaston K, et al.
Bioorg Med Chem
. 2012 Mar;
20(8):2490-7.
PMID: 22459210
Novel pyrazine carboxamides bearing hydrophilic poly(ethylene glycol) (PEG) moieties were designed, synthesized, and evaluated for use as fluorescent glomerular filtration rate (GFR) tracer agents. Among these, compounds 4d and 5c...
5.
Lee N, Sun G, Neumann W, Freskos J, Shieh J, Dorshow R, et al.
Adv Mater
. 2011 Nov;
21(13):1344-1348.
PMID: 22058610
A pH-insensitive fluorophore is made to give pH-driven responses through its covalent incorporation within a nanostructure derived from pH-responsive polymers. Fluorophore-shell-crosslinked nanoparticles (SCKs) demonstrate notable enhancement of photophysical properties, in...
6.
Lee N, Lin L, Neumann W, Freskos J, Karwa A, Shieh J, et al.
Small
. 2011 Jun;
7(14):1998-2003.
PMID: 21678552
No abstract available.
7.
Rajagopalan R, Neumann W, Poreddy A, Fitch R, Freskos J, Asmelash B, et al.
J Med Chem
. 2011 Jun;
54(14):5048-58.
PMID: 21667980
Various hydrophilic pyrazine-bis(carboxamides) derived from 3,5-diamino-pyrazine-2,5-dicarboxylic acid bearing neutral and anionic groups were prepared and evaluated for use as fluorescent glomerular filtration rate (GFR) tracer agents. Among these, the dianionic...
8.
Sun G, Cui H, Lin L, Lee N, Yang C, Neumann W, et al.
J Am Chem Soc
. 2011 May;
133(22):8534-43.
PMID: 21574617
Pyrazine-labeled multicompartment nanostructures are shown to exhibit enhanced pH-responsive blue-shifted fluorescence emission intensities compared to their simpler core-shell spherical analogs. An amphiphilic linear triblock terpolymer of ethylene oxide, N-acryloxysuccinimide, and...
9.
Fobian Y, Freskos J, Barta T, Bedell L, Heintz R, Kassab D, et al.
Bioorg Med Chem Lett
. 2011 Apr;
21(10):2823-5.
PMID: 21493063
Continuing our interest in designing compounds preferentially potent and selective for MMP-13, we report on a series of hydroxamic acids with a flexible amide P1' substituents. We identify an amide...
10.
Becker D, Barta T, Bedell L, Boehm T, Bond B, Carroll J, et al.
J Med Chem
. 2010 Aug;
53(18):6653-80.
PMID: 20726512
α-Sulfone-α-piperidine and α-tetrahydropyranyl hydroxamates were explored that are potent inhibitors of MMP's-2, -9, and -13 that spare MMP-1, with oral efficacy in inhibiting tumor growth in mice and left-ventricular hypertrophy...