William L Neumann
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Explore the profile of William L Neumann including associated specialties, affiliations and a list of published articles.
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46
Citations
1028
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Recent Articles
1.
Crider A, Hospital A, Sandoval K, Neumann W, Kukielski S, Garic L, et al.
RSC Med Chem
. 2024 Dec;
PMID: 39713483
Somatostatin receptor-4 (SST) is a therapeutic target for several conditions, including Alzheimer's disease, seizures, neuropsychiatric disorders, and pain. Our previous work on 1,2,4-triazole derivatives led to enhanced SST binding affinity,...
2.
Neumann W, Sandoval K, Mobayen S, Minaeian M, Kukielski S, Srabony K, et al.
RSC Med Chem
. 2021 Aug;
12(8):1352-1365.
PMID: 34458738
Somatostatin receptor-4 (SST) is highly expressed in brain regions affiliated with learning and memory. SST agonist treatment may act to mitigate Alzheimer's disease (AD) pathology. An integrated approach to SST...
3.
Doyle T, Hutchinson M, Braden K, Janes K, Staikopoulos V, Chen Z, et al.
J Neuroinflammation
. 2020 Oct;
17(1):314.
PMID: 33092620
Opioid therapies for chronic pain are undermined by many adverse side effects that reduce their efficacy and lead to dependence, abuse, reduced quality of life, and even death. We have...
4.
Mostyka M, Shia J, Neumann W, Whitney-Miller C, Feely M, Yantiss R
Am J Surg Pathol
. 2020 Aug;
45(2):209-214.
PMID: 32826528
Reactivation of latent varicella zoster virus (VZV) may be limited to a dermatome or involve multiple organs, including the gastrointestinal tract. Although gastrointestinal manifestations of disseminated zoster have been likened...
5.
Yu H, Liu Y, Wang M, Restrepo R, Wang D, Kalogeris T, et al.
Am J Physiol Heart Circ Physiol
. 2020 Aug;
319(3):H705-H721.
PMID: 32762560
Myeloperoxidase (MPO)-derived hypochlorous (HOCl) reacts with membrane plasmalogens to yield α-chlorofatty aldehydes such as 2-chlorofatty aldehyde (2-ClFALD) and its metabolite 2-chlorofatty acid (2-ClFA). Recent studies showed that 2-ClFALD and 2-ClFA...
6.
Doyle T, Janes K, Chen Z, Grace P, Esposito E, Cuzzocrea S, et al.
Pain
. 2020 Apr;
161(9):2107-2118.
PMID: 32301840
Morphine-induced alterations in sphingolipid metabolism in the spinal cord and increased formation of the bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) have been implicated in the development of morphine-induced hyperalgesia (OIH; increased...
7.
Jackson D, Panopoulos M, Neumann W, Turner K, Cantarel B, Thompson-Snipes L, et al.
Gut
. 2020 Mar;
69(11):1928-1938.
PMID: 32111635
Objective: Although perturbations in mitochondrial function and structure have been described in the intestinal epithelium of Crohn's disease and ulcerative colitis patients, the role of epithelial mitochondrial stress in the...
8.
Rosati R, Shahab M, Neumann W, Jamesdaniel S
Exp Cell Res
. 2019 May;
381(1):105-111.
PMID: 31078568
JAK/STAT pathway is one among the several oxidative stress-responsive signaling pathways that play a critical role in facilitating cisplatin-induced ototoxicity. Cisplatin treatment decreases the levels of cochlear LMO4, which acts...
9.
Chen Z, Doyle T, Luongo L, Largent-Milnes T, Giancotti L, Kolar G, et al.
Proc Natl Acad Sci U S A
. 2019 May;
116(21):10557-10562.
PMID: 31068460
Neuropathic pain afflicts millions of individuals and represents a major health problem for which there is limited effective and safe therapy. Emerging literature links altered sphingolipid metabolism to nociceptive processing....
10.
McPherson T, Neumann W, Goolsby M, Kolling W
Int J Pharm Compd
. 2018 Jul;
22(4):329-334.
PMID: 30021188
Tetracaine is a potent ester-type local anesthetic. Recent publications describe the use of TC free base in topical anesthetic formulations containing propylene glycol. While solvolysis of tetracaine in propylene glycol...